Felbamate reduces hypoxic-ischemic brain damage in vivo

The neuroprotective effects of felbamate were tested in a model of incomplete cerebral ischemia and hypoxia in 7-day-old rat pups. Felbamate pretreatment (300 mg/kg) reduced the surface of infarcted cortex following bilateral carotid ligation, by 42–49% compared to saline and dimethylsulfoxide (DMSO...

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Veröffentlicht in:	European journal of pharmacology 1992-03, Vol.212 (2), p.275-278
Hauptverfasser:	Wasterlain, Claude G., Adams, Lisa M., Hattori, Haruo, Schwartz, Phillip H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants Anticonvulsants - pharmacokinetics Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Asphyxia neonatorum Behavior, Animal - drug effects Biological and medical sciences Body Temperature - drug effects Brain Ischemia - drug therapy Brain Ischemia - pathology Cerebral infarction Cerebral ischemia Felbamate Female Hippocampus - drug effects Hippocampus - pathology Hypoxia, Brain - drug therapy Hypoxia, Brain - pathology Medical sciences Necrosis Neonate Neuropharmacology Pharmacology. Drug treatments Phenylcarbamates Propylene Glycols - pharmacokinetics Propylene Glycols - therapeutic use Rats Rats, Inbred Strains
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Zusammenfassung:	The neuroprotective effects of felbamate were tested in a model of incomplete cerebral ischemia and hypoxia in 7-day-old rat pups. Felbamate pretreatment (300 mg/kg) reduced the surface of infarcted cortex following bilateral carotid ligation, by 42–49% compared to saline and dimethylsulfoxide (DMSO) controls, respectively. The number of necrotic neurons in the d dentate gyrus was reduced by 77% over both DMSO controls and saline controls. These results suggest that felbamate deserves further evaluation for its therapeutic potential in hypoxia-ischemia.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(92)90343-3