Detection of a frequent polymorphism in exon 10 of the low-density lipoprotein receptor gene

DNA sequencing of enzymatically-amplified exons of the low-density lipoprotein receptor gene from several individuals revealed a polymorphism in exon 10 of the gene. The codon for arginine 450 was converted from AGG to AGA in some alleles.

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Bibliographische Detailangaben
Veröffentlicht in:	Human genetics 1992-05, Vol.89 (3), p.362-362
Hauptverfasser:	WARNICH, L, KOTZE, M. J, LANGENHOVEN, E, RETIEF, A. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Arginine - genetics Base Sequence Biological and medical sciences exons Exons - genetics Fundamental and applied biological sciences. Psychology genes Humans lipoprotein (low density) man Molecular and cellular biology Molecular Sequence Data Mutation - genetics Oligodeoxyribonucleotides - genetics Polymerase Chain Reaction Polymorphism, Genetic - genetics receptors Receptors, LDL - genetics restriction fragment length polymorphism
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Beschreibung
Zusammenfassung:	DNA sequencing of enzymatically-amplified exons of the low-density lipoprotein receptor gene from several individuals revealed a polymorphism in exon 10 of the gene. The codon for arginine 450 was converted from AGG to AGA in some alleles.
ISSN:	0340-6717 1432-1203
DOI:	10.1007/BF00220563