Retinal pigment epithelium implantation in the rabbit: technique and morphology
Dysfunction of the retinal pigment epithelium (RPE) is a major component of many degenerative disorders of the retina. We have developed a modified pars plana technique for subretinal implantation of homologous, cultured, carbon-loaded RPE cells in the rabbit. The natural history and morphologic beh...
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Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 1992-05, Vol.230 (3), p.292-300 |
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creator | EL DIRINI, A. A HSIN-MIN WANG OGDEN, T. E RYAN, S. J |
description | Dysfunction of the retinal pigment epithelium (RPE) is a major component of many degenerative disorders of the retina. We have developed a modified pars plana technique for subretinal implantation of homologous, cultured, carbon-loaded RPE cells in the rabbit. The natural history and morphologic behavior of the implanted RPE cells for up to 6 weeks after transplantation were observed in successful procedures. |
doi_str_mv | 10.1007/BF00176307 |
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A ; HSIN-MIN WANG ; OGDEN, T. E ; RYAN, S. J</creator><creatorcontrib>EL DIRINI, A. A ; HSIN-MIN WANG ; OGDEN, T. E ; RYAN, S. J</creatorcontrib><description>Dysfunction of the retinal pigment epithelium (RPE) is a major component of many degenerative disorders of the retina. We have developed a modified pars plana technique for subretinal implantation of homologous, cultured, carbon-loaded RPE cells in the rabbit. The natural history and morphologic behavior of the implanted RPE cells for up to 6 weeks after transplantation were observed in successful procedures.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/BF00176307</identifier><identifier>PMID: 1597298</identifier><identifier>CODEN: GACODL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Carbon ; Cells, Cultured ; Medical sciences ; Pigment Epithelium of Eye - transplantation ; Pigment Epithelium of Eye - ultrastructure ; Rabbits ; Retina - surgery ; Retina - ultrastructure ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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The natural history and morphologic behavior of the implanted RPE cells for up to 6 weeks after transplantation were observed in successful procedures.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbon</subject><subject>Cells, Cultured</subject><subject>Medical sciences</subject><subject>Pigment Epithelium of Eye - transplantation</subject><subject>Pigment Epithelium of Eye - ultrastructure</subject><subject>Rabbits</subject><subject>Retina - surgery</subject><subject>Retina - ultrastructure</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the eye and orbit</subject><subject>Transplantation, Homologous - methods</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUxoMoc04v3oUcxINQTRqbJt7mcCoMBqKwW0nT1y3SpjVJD_vvzdhwl_fgfb_3-N6H0DUlD5SQ_PFlTgjNOSP5CRrTJ5YlOUlXp2hM8pQmgqWrc3Th_Q8hJIp0hEY0k3kqxRgtPyEYqxrcm3ULNmDoTdhAY4YWm7ZvlA0qmM5iY3GcY6fK0oRnHEBvrPkdACtb4bZz_aZruvX2Ep3VqvFwdegT9D1__Zq9J4vl28dsukg0ozQkXECtea1krUpZiazUumLAYpUi40IAZ1yXXKRQlYSynDHQgkIqM6h43GQTdLe_27suuvChaI3X0ETD0A2-2H0XF0UE7_egdp33Duqid6ZVbltQUuzSK47pRfjmcHUoW6iO6D6uqN8edOW1amqnrDb-H8tSIRnN2B8kSHgi</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>EL DIRINI, A. A</creator><creator>HSIN-MIN WANG</creator><creator>OGDEN, T. E</creator><creator>RYAN, S. 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A</creatorcontrib><creatorcontrib>HSIN-MIN WANG</creatorcontrib><creatorcontrib>OGDEN, T. E</creatorcontrib><creatorcontrib>RYAN, S. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EL DIRINI, A. A</au><au>HSIN-MIN WANG</au><au>OGDEN, T. E</au><au>RYAN, S. 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subjects | Animals Biological and medical sciences Carbon Cells, Cultured Medical sciences Pigment Epithelium of Eye - transplantation Pigment Epithelium of Eye - ultrastructure Rabbits Retina - surgery Retina - ultrastructure Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Transplantation, Homologous - methods |
title | Retinal pigment epithelium implantation in the rabbit: technique and morphology |
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