Retinal pigment epithelium implantation in the rabbit: technique and morphology

Dysfunction of the retinal pigment epithelium (RPE) is a major component of many degenerative disorders of the retina. We have developed a modified pars plana technique for subretinal implantation of homologous, cultured, carbon-loaded RPE cells in the rabbit. The natural history and morphologic beh...

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Veröffentlicht in:	Graefe's archive for clinical and experimental ophthalmology 1992-05, Vol.230 (3), p.292-300
Hauptverfasser:	EL DIRINI, A. A, HSIN-MIN WANG, OGDEN, T. E, RYAN, S. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carbon Cells, Cultured Medical sciences Pigment Epithelium of Eye - transplantation Pigment Epithelium of Eye - ultrastructure Rabbits Retina - surgery Retina - ultrastructure Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Transplantation, Homologous - methods
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Beschreibung
Zusammenfassung:	Dysfunction of the retinal pigment epithelium (RPE) is a major component of many degenerative disorders of the retina. We have developed a modified pars plana technique for subretinal implantation of homologous, cultured, carbon-loaded RPE cells in the rabbit. The natural history and morphologic behavior of the implanted RPE cells for up to 6 weeks after transplantation were observed in successful procedures.
ISSN:	0721-832X 1435-702X
DOI:	10.1007/BF00176307