Isolation and Structure of the Cytotoxic Cycloheptapeptide Phakellistatin 13

A new cyclic heptapeptide phakellistatin 13 (1) had been isolated from the sponge Phakellia fusca Thiele, collected at Yongxing Island of China. Its structure was elucidated as cyclo-(Pro-Trp-Leu-Thr-Pro-Gly-Phe) on the basis of MS, UV, IR, and high-field NMR (600 MHz) analysis. The compound was sig...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2003-01, Vol.66 (1), p.146-148
Hauptverfasser:	Li, Wen-Lin, Yi, Yang-Hua, Wu, Hou-Ming, Xu, Qiang-Zhi, Tang, Hai-Feng, Zhou, Da-Zheng, Lin, Hou-Wen, Wang, Zhong-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Carcinoma, Hepatocellular China Drug Screening Assays, Antitumor General pharmacology Humans Medical sciences Molecular Structure Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Tumor Cells, Cultured - drug effects
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Zusammenfassung:	A new cyclic heptapeptide phakellistatin 13 (1) had been isolated from the sponge Phakellia fusca Thiele, collected at Yongxing Island of China. Its structure was elucidated as cyclo-(Pro-Trp-Leu-Thr-Pro-Gly-Phe) on the basis of MS, UV, IR, and high-field NMR (600 MHz) analysis. The compound was significantly cytotoxic against the human hepatoma BEL-7404 cell line with an ED50 < 10-2 μg/mL.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np020223y