t(4;12)(q11;p13): a rare chromosomal translocation in acute myeloid leukemia

We present a case of acute myeloid leukemia with t(4;12). This translocation is rare and has been observed in acute leukemias with different but immature phenotypes. To the best of our knowledge, there are around 15 descriptions of t(4;12) in AML, and most interesting, presenting morphological aspec...

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Veröffentlicht in:	Leukemia research 2003-04, Vol.27 (4), p.363-366
Hauptverfasser:	Chauffaille, Maria de Lourdes L.F., Fermino, Fabiana A., Pelloso, Luis A.F., Silva, Maria R.R., Bordin, José O., Yamamoto, Mihoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute myeloid leukemia Adult Biological and medical sciences Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 4 Cytogenetic Analysis Dysplasia Fatal Outcome Hematologic and hematopoietic diseases Humans Immunophenotyping Leukemia, Myeloid - genetics Leukemia, Myeloid - pathology Leukemia, Myeloid - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Pseudo-lymphoid morphology t(4 12) Translocation, Genetic
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Zusammenfassung:	We present a case of acute myeloid leukemia with t(4;12). This translocation is rare and has been observed in acute leukemias with different but immature phenotypes. To the best of our knowledge, there are around 15 descriptions of t(4;12) in AML, and most interesting, presenting morphological aspects of a pseudo-lymphoid cell with dysplasia of other series.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/S0145-2126(02)00172-8