Determination of Nifedipine in plasma by a rapid capillary gas chromatographic method

Determination of Nifedipine in plasma by a rapid capillary gas chromatographic method

A rapid, specific and reliable gas chromatographic assay procedure for Nifedipine in plasma has been developed. With a single‐step solvent extraction, and electron capture detection, the method is sensitive to 0.5 ng/mL of plasma and the standard curve is linear from 0.5 to 500 ng/mL. Samples are pr...

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Veröffentlicht in:Biomedical chromatography 1992-01, Vol.6 (1), p.20-23
Hauptverfasser: Guellec, C. Le, Bun, H., Giocanti, M., Durand, A.
Format: Artikel
Sprache:eng
Schlagworte:
Chromatography, Gas
Humans
Nifedipine - blood
Reproducibility of Results
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Zusammenfassung:A rapid, specific and reliable gas chromatographic assay procedure for Nifedipine in plasma has been developed. With a single‐step solvent extraction, and electron capture detection, the method is sensitive to 0.5 ng/mL of plasma and the standard curve is linear from 0.5 to 500 ng/mL. Samples are protected from light to prevent formation of photodecomposition products. The method has been used to monitor drug concentrations in patients receiving therapeutic doses.
ISSN:0269-3879
1099-0801
DOI:10.1002/bmc.1130060107