The effect of hypovolemia on the renal and cardiovascular responses to atrial natriuretic factor (ANF) infusion

The effect of hypovolemia on the renal and cardiovascular responses to atrial natriuretic factor (ANF) infusion

The renal and cardiovascular effects of ANF infusion have been examined in separate series of experiments; in conscious instrumented sheep following either hemorrhage (10 mL/kg body weight) or removal of 500 mL of plasma by ultrafiltration. Renal arterial infusion of hANF (99–126) at 50 μg/h increas...

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Veröffentlicht in:Life sciences (1973) 1992, Vol.50 (24), p.1905-1912
Hauptverfasser: Yates, Neale A., Parkes, David G., Coghlan, John P., Scoggins, Bruce A., McDougall, John G.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Apud cells. Peptide and protein hormones. Growth factors
Atrial Natriuretic Factor - pharmacology
Biological and medical sciences
Blood Volume - physiology
Cardiovascular Physiological Phenomena
Cardiovascular System - drug effects
Consciousness
Fundamental and applied biological sciences. Psychology
Hemodynamics - drug effects
Hemodynamics - physiology
Hemofiltration
Infusions, Intravenous
Kidney - drug effects
Kidney - physiology
Renin
Sheep
Ultrafiltration
Vertebrates: endocrinology
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Zusammenfassung:The renal and cardiovascular effects of ANF infusion have been examined in separate series of experiments; in conscious instrumented sheep following either hemorrhage (10 mL/kg body weight) or removal of 500 mL of plasma by ultrafiltration. Renal arterial infusion of hANF (99–126) at 50 μg/h increased sodium excretion from 99 ± 30 to 334 ± 102 (p
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(92)90551-Y