Apoptosis: Mitochondrial Membrane Permeabilization – The (W)hole Story?

One critical step of apoptosis is the release of mitochondrial proteins through the outer mitochondrial membrane. Recent work shows that two pro-apoptotic Bcl-2 family proteins, Bax and Bid, as well as the mitochondrion-specific lipid cardiolipin may cooperate in chemically defined liposomes to gene...

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Veröffentlicht in:	Current biology 2003-01, Vol.13 (2), p.R71-R73
Hauptverfasser:	Zamzami, Naoufal, Kroemer, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology bcl-2-Associated X Protein BH3 Interacting Domain Death Agonist Protein Cardiolipins - metabolism Carrier Proteins - metabolism Caspases - metabolism In Vitro Techniques Intracellular Membranes - metabolism Matrix Metalloproteinases - metabolism Mitochondria - metabolism Models, Biological Permeability Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2
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Beschreibung
Zusammenfassung:	One critical step of apoptosis is the release of mitochondrial proteins through the outer mitochondrial membrane. Recent work shows that two pro-apoptotic Bcl-2 family proteins, Bax and Bid, as well as the mitochondrion-specific lipid cardiolipin may cooperate in chemically defined liposomes to generate a protein-permeable conduit, relaunching the debate on the identity of the pore responsible for mitochondrial membrane permeabilization during apoptosis.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/S0960-9822(02)01433-1