Fluoroquinolone Resistance in Streptococcus pyogenes
Streptococcus pyogenes isolated from blood and urine samples obtained from a 78-year-old woman was tested for susceptibility, and fluoroquinolone resistance (minimum inhibitory concentration of levofloxacin, 16 μg/mL) was found. DNA amplification and sequencing revealed a serine81→tyrosine substitut...
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| Veröffentlicht in: | Clinical infectious diseases 2003-02, Vol.36 (3), p.380-383 |
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| container_end_page | 383 |
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| container_title | Clinical infectious diseases |
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| creator | Richter, Sandra S. Diekema, Daniel J. Heilmann, Kris P. Almer, Laurel S. Shortridge, Virginia D. Zeitler, Rod Flamm, Robert K. Doern, Gary V. |
| description | Streptococcus pyogenes isolated from blood and urine samples obtained from a 78-year-old woman was tested for susceptibility, and fluoroquinolone resistance (minimum inhibitory concentration of levofloxacin, 16 μg/mL) was found. DNA amplification and sequencing revealed a serine81→tyrosine substitution in gyrA and 2 substitutions in parC: serine79→phenylalanine and alanine121→valine. This is the second report of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance. |
| doi_str_mv | 10.1086/345904 |
| format | Article |
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DNA amplification and sequencing revealed a serine81→tyrosine substitution in gyrA and 2 substitutions in parC: serine79→phenylalanine and alanine121→valine. This is the second report of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/345904</identifier><identifier>PMID: 12539083</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Amino Acid Substitution ; Anti-Infective Agents - pharmacology ; Antimicrobials ; Bacteremia ; Blood ; Brief Report ; DNA Gyrase - genetics ; DNA Topoisomerase IV - genetics ; Drug Resistance, Bacterial - genetics ; Female ; Fluoroquinolones ; Genetic mutation ; Hospitalization ; Humans ; Infections ; Levofloxacin ; Microbial Sensitivity Tests ; Ofloxacin - pharmacology ; Pleural effusion ; Streptococcal Infections - microbiology ; Streptococcus pyogenes ; Streptococcus pyogenes - drug effects ; Streptococcus pyogenes - genetics ; Streptococcus pyogenes - isolation & purification ; Surveillance</subject><ispartof>Clinical infectious diseases, 2003-02, Vol.36 (3), p.380-383</ispartof><rights>Copyright 2003 The Infectious Diseases Society of America</rights><rights>2003 by the Infectious Diseases Society of America 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-b46a43b9d86697fdfbfaf46b4bfc47722fdc85f7e420e3e35e5bc2a5b4d733123</citedby><cites>FETCH-LOGICAL-c416t-b46a43b9d86697fdfbfaf46b4bfc47722fdc85f7e420e3e35e5bc2a5b4d733123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4462310$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4462310$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12539083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Richter, Sandra S.</creatorcontrib><creatorcontrib>Diekema, Daniel J.</creatorcontrib><creatorcontrib>Heilmann, Kris P.</creatorcontrib><creatorcontrib>Almer, Laurel S.</creatorcontrib><creatorcontrib>Shortridge, Virginia D.</creatorcontrib><creatorcontrib>Zeitler, Rod</creatorcontrib><creatorcontrib>Flamm, Robert K.</creatorcontrib><creatorcontrib>Doern, Gary V.</creatorcontrib><title>Fluoroquinolone Resistance in Streptococcus pyogenes</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>Streptococcus pyogenes isolated from blood and urine samples obtained from a 78-year-old woman was tested for susceptibility, and fluoroquinolone resistance (minimum inhibitory concentration of levofloxacin, 16 μg/mL) was found. DNA amplification and sequencing revealed a serine81→tyrosine substitution in gyrA and 2 substitutions in parC: serine79→phenylalanine and alanine121→valine. This is the second report of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.</description><subject>Amino Acid Substitution</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antimicrobials</subject><subject>Bacteremia</subject><subject>Blood</subject><subject>Brief Report</subject><subject>DNA Gyrase - genetics</subject><subject>DNA Topoisomerase IV - genetics</subject><subject>Drug Resistance, Bacterial - genetics</subject><subject>Female</subject><subject>Fluoroquinolones</subject><subject>Genetic mutation</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infections</subject><subject>Levofloxacin</subject><subject>Microbial Sensitivity Tests</subject><subject>Ofloxacin - pharmacology</subject><subject>Pleural effusion</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcus pyogenes</subject><subject>Streptococcus pyogenes - drug effects</subject><subject>Streptococcus pyogenes - genetics</subject><subject>Streptococcus pyogenes - isolation & purification</subject><subject>Surveillance</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9LwzAYh4MoTqd-ApF58VZNmv9HGc4pQ8EpiJfQpm-ks2tq04L79nZ0TC_iKS_8Hh7Cg9AJwZcEK3FFGdeY7aADwqmMBNdkt7sxVxFTVA3QYQgLjAlRmO-jAYk51VjRA8QmRetr_9nmpS98CaMnCHloktLCKC9H86aGqvHWW9uGUbXy71BCOEJ7LikCHG_eIXqZ3DyPp9Hs8fZufD2LLCOiiVImEkZTnSkhtHSZS13imEhZ6iyTMo5dZhV3EliMgQLlwFMbJzxlmaSUxHSILnpvtf4hhMYs82ChKJISfBuMjLVkgul_QaIU0RL_Mtrah1CDM1WdL5N6ZQg265CmD9mBZxtjmy4h-8E25TrgvAd8W_0tOe2ZRWh8vaUYEzEluJujfu6Cw9d2TuoPIySV3Exf34wez8f3D0SZGf0GRSqPpg</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Richter, Sandra S.</creator><creator>Diekema, Daniel J.</creator><creator>Heilmann, Kris P.</creator><creator>Almer, Laurel S.</creator><creator>Shortridge, Virginia D.</creator><creator>Zeitler, Rod</creator><creator>Flamm, Robert K.</creator><creator>Doern, Gary V.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Fluoroquinolone Resistance in Streptococcus pyogenes</title><author>Richter, Sandra S. ; Diekema, Daniel J. ; Heilmann, Kris P. ; Almer, Laurel S. ; Shortridge, Virginia D. ; Zeitler, Rod ; Flamm, Robert K. ; Doern, Gary V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-b46a43b9d86697fdfbfaf46b4bfc47722fdc85f7e420e3e35e5bc2a5b4d733123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Amino Acid Substitution</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antimicrobials</topic><topic>Bacteremia</topic><topic>Blood</topic><topic>Brief Report</topic><topic>DNA Gyrase - genetics</topic><topic>DNA Topoisomerase IV - genetics</topic><topic>Drug Resistance, Bacterial - genetics</topic><topic>Female</topic><topic>Fluoroquinolones</topic><topic>Genetic mutation</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Infections</topic><topic>Levofloxacin</topic><topic>Microbial Sensitivity Tests</topic><topic>Ofloxacin - pharmacology</topic><topic>Pleural effusion</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcus pyogenes</topic><topic>Streptococcus pyogenes - drug effects</topic><topic>Streptococcus pyogenes - genetics</topic><topic>Streptococcus pyogenes - isolation & purification</topic><topic>Surveillance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Richter, Sandra S.</creatorcontrib><creatorcontrib>Diekema, Daniel J.</creatorcontrib><creatorcontrib>Heilmann, Kris P.</creatorcontrib><creatorcontrib>Almer, Laurel S.</creatorcontrib><creatorcontrib>Shortridge, Virginia D.</creatorcontrib><creatorcontrib>Zeitler, Rod</creatorcontrib><creatorcontrib>Flamm, Robert K.</creatorcontrib><creatorcontrib>Doern, Gary V.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richter, Sandra S.</au><au>Diekema, Daniel J.</au><au>Heilmann, Kris P.</au><au>Almer, Laurel S.</au><au>Shortridge, Virginia D.</au><au>Zeitler, Rod</au><au>Flamm, Robert K.</au><au>Doern, Gary V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluoroquinolone Resistance in Streptococcus pyogenes</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>36</volume><issue>3</issue><spage>380</spage><epage>383</epage><pages>380-383</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Streptococcus pyogenes isolated from blood and urine samples obtained from a 78-year-old woman was tested for susceptibility, and fluoroquinolone resistance (minimum inhibitory concentration of levofloxacin, 16 μg/mL) was found. DNA amplification and sequencing revealed a serine81→tyrosine substitution in gyrA and 2 substitutions in parC: serine79→phenylalanine and alanine121→valine. This is the second report of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>12539083</pmid><doi>10.1086/345904</doi><tpages>4</tpages></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE; Oxford University Press Journals Current; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Amino Acid Substitution Anti-Infective Agents - pharmacology Antimicrobials Bacteremia Blood Brief Report DNA Gyrase - genetics DNA Topoisomerase IV - genetics Drug Resistance, Bacterial - genetics Female Fluoroquinolones Genetic mutation Hospitalization Humans Infections Levofloxacin Microbial Sensitivity Tests Ofloxacin - pharmacology Pleural effusion Streptococcal Infections - microbiology Streptococcus pyogenes Streptococcus pyogenes - drug effects Streptococcus pyogenes - genetics Streptococcus pyogenes - isolation & purification Surveillance |
| title | Fluoroquinolone Resistance in Streptococcus pyogenes |
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