Fluoroquinolone Resistance in Streptococcus pyogenes

Streptococcus pyogenes isolated from blood and urine samples obtained from a 78-year-old woman was tested for susceptibility, and fluoroquinolone resistance (minimum inhibitory concentration of levofloxacin, 16 μg/mL) was found. DNA amplification and sequencing revealed a serine81→tyrosine substitut...

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Veröffentlicht in:	Clinical infectious diseases 2003-02, Vol.36 (3), p.380-383
Hauptverfasser:	Richter, Sandra S., Diekema, Daniel J., Heilmann, Kris P., Almer, Laurel S., Shortridge, Virginia D., Zeitler, Rod, Flamm, Robert K., Doern, Gary V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Anti-Infective Agents - pharmacology Antimicrobials Bacteremia Blood Brief Report DNA Gyrase - genetics DNA Topoisomerase IV - genetics Drug Resistance, Bacterial - genetics Female Fluoroquinolones Genetic mutation Hospitalization Humans Infections Levofloxacin Microbial Sensitivity Tests Ofloxacin - pharmacology Pleural effusion Streptococcal Infections - microbiology Streptococcus pyogenes Streptococcus pyogenes - drug effects Streptococcus pyogenes - genetics Streptococcus pyogenes - isolation & purification Surveillance
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Beschreibung
Zusammenfassung:	Streptococcus pyogenes isolated from blood and urine samples obtained from a 78-year-old woman was tested for susceptibility, and fluoroquinolone resistance (minimum inhibitory concentration of levofloxacin, 16 μg/mL) was found. DNA amplification and sequencing revealed a serine81→tyrosine substitution in gyrA and 2 substitutions in parC: serine79→phenylalanine and alanine121→valine. This is the second report of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/345904