A New Strategy for Neurochemical Photodelivery: Metal−Ligand Heterolytic Cleavage
A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal−ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule i...
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| Veröffentlicht in: | Journal of the American Chemical Society 2003-01, Vol.125 (4), p.882-883 |
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| container_end_page | 883 |
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| container_issue | 4 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 125 |
| creator | Zayat, Leonardo Calero, Cecilia Alborés, Pablo Baraldo, Luis Etchenique, Roberto |
| description | A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal−ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed. |
| doi_str_mv | 10.1021/ja0278943 |
| format | Article |
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The approach is based on heterolytic photocleavage of a metal−ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed.</description><identifier>ISSN: 0002-7863</identifier><identifier>EISSN: 1520-5126</identifier><identifier>DOI: 10.1021/ja0278943</identifier><identifier>PMID: 12537482</identifier><identifier>CODEN: JACSAT</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject><![CDATA[2,2'-Dipyridyl - administration & dosage ; 2,2'-Dipyridyl - analogs & derivatives ; 2,2'-Dipyridyl - chemistry ; 2,2'-Dipyridyl - pharmacokinetics ; 4-Aminopyridine - administration & dosage ; 4-Aminopyridine - chemistry ; 4-Aminopyridine - pharmacokinetics ; Action Potentials - drug effects ; Action Potentials - physiology ; Analysis ; Animals ; Biological and medical sciences ; Drug Carriers - administration & dosage ; Drug Carriers - chemistry ; Drug Carriers - pharmacokinetics ; Ganglia - cytology ; Ganglia - metabolism ; Ganglia - physiology ; General pharmacology ; Leeches ; Medical sciences ; Membrane Potentials - drug effects ; Membrane Potentials - physiology ; Neurons - drug effects ; Neurons - metabolism ; Neurons - physiology ; Organometallic Compounds - administration & dosage ; Organometallic Compounds - chemistry ; Organometallic Compounds - pharmacokinetics ; Oxidation-Reduction ; Pharmacology. Drug treatments ; Photochemistry ; Potassium Channel Blockers - administration & dosage ; Potassium Channel Blockers - chemistry ; Potassium Channel Blockers - pharmacokinetics]]></subject><ispartof>Journal of the American Chemical Society, 2003-01, Vol.125 (4), p.882-883</ispartof><rights>Copyright © 2003 American Chemical Society</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a445t-20d7c9b80a9f3ea6f4c28a66c448f2aa37581f139a0dcaffa1b05c541c3b93d33</citedby><cites>FETCH-LOGICAL-a445t-20d7c9b80a9f3ea6f4c28a66c448f2aa37581f139a0dcaffa1b05c541c3b93d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ja0278943$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ja0278943$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2763,27075,27923,27924,56737,56787</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14502186$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12537482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zayat, Leonardo</creatorcontrib><creatorcontrib>Calero, Cecilia</creatorcontrib><creatorcontrib>Alborés, Pablo</creatorcontrib><creatorcontrib>Baraldo, Luis</creatorcontrib><creatorcontrib>Etchenique, Roberto</creatorcontrib><title>A New Strategy for Neurochemical Photodelivery: Metal−Ligand Heterolytic Cleavage</title><title>Journal of the American Chemical Society</title><addtitle>J. Am. Chem. Soc</addtitle><description>A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal−ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed.</description><subject>2,2'-Dipyridyl - administration & dosage</subject><subject>2,2'-Dipyridyl - analogs & derivatives</subject><subject>2,2'-Dipyridyl - chemistry</subject><subject>2,2'-Dipyridyl - pharmacokinetics</subject><subject>4-Aminopyridine - administration & dosage</subject><subject>4-Aminopyridine - chemistry</subject><subject>4-Aminopyridine - pharmacokinetics</subject><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>Analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Drug Carriers - administration & dosage</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - pharmacokinetics</subject><subject>Ganglia - cytology</subject><subject>Ganglia - metabolism</subject><subject>Ganglia - physiology</subject><subject>General pharmacology</subject><subject>Leeches</subject><subject>Medical sciences</subject><subject>Membrane Potentials - drug effects</subject><subject>Membrane Potentials - physiology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Neurons - physiology</subject><subject>Organometallic Compounds - administration & dosage</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - pharmacokinetics</subject><subject>Oxidation-Reduction</subject><subject>Pharmacology. Drug treatments</subject><subject>Photochemistry</subject><subject>Potassium Channel Blockers - administration & dosage</subject><subject>Potassium Channel Blockers - chemistry</subject><subject>Potassium Channel Blockers - pharmacokinetics</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkD1PG0EQhlcRKBgnBX8AXUMkigv7dV_piPmUnATJTtrVeG_WnHP2wu4e4I4S2vxEfgmLbOEm1WhmHr2aeQjZY_Qro5wdzYDyoqyk-EB6LOM0zRjPt0iPUsrToszFDtn1fhZbyUv2kewwnolClrxH_hwnP_E-GQUHAafLxFgXB52z-hrnjYY2ubq2wdbYNnfolt9eHp-THxigfXn6N2ymsKiTCwzobLsMjU4GLcIdTPET2TbQevy8rn3y--x0PLhIh7_OLwfHwxSkzELKaV3oalJSqIxAyI3UvIQ811KWhgOIIiuZYaICWmswBtiEZjqTTItJJWoh-uTLKvfG2dsOfVDzxmtsW1ig7bwqeFW8_RzBwxWonfXeoVE3rpmDWypG1ZtE9S4xsvvr0G4yx3pDrq1F4GANgI-KjIOFbvyGk1kMjNr7JF1xjQ_48L4H91flRfxNja9Gip-MRyejIVPfN7mgvZrZzi2iu_8c-Ar_65Xm</recordid><startdate>20030129</startdate><enddate>20030129</enddate><creator>Zayat, Leonardo</creator><creator>Calero, Cecilia</creator><creator>Alborés, Pablo</creator><creator>Baraldo, Luis</creator><creator>Etchenique, Roberto</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030129</creationdate><title>A New Strategy for Neurochemical Photodelivery: Metal−Ligand Heterolytic Cleavage</title><author>Zayat, Leonardo ; Calero, Cecilia ; Alborés, Pablo ; Baraldo, Luis ; Etchenique, Roberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a445t-20d7c9b80a9f3ea6f4c28a66c448f2aa37581f139a0dcaffa1b05c541c3b93d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>2,2'-Dipyridyl - administration & dosage</topic><topic>2,2'-Dipyridyl - analogs & derivatives</topic><topic>2,2'-Dipyridyl - chemistry</topic><topic>2,2'-Dipyridyl - pharmacokinetics</topic><topic>4-Aminopyridine - administration & dosage</topic><topic>4-Aminopyridine - chemistry</topic><topic>4-Aminopyridine - pharmacokinetics</topic><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>Analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Drug Carriers - administration & dosage</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - pharmacokinetics</topic><topic>Ganglia - cytology</topic><topic>Ganglia - metabolism</topic><topic>Ganglia - physiology</topic><topic>General pharmacology</topic><topic>Leeches</topic><topic>Medical sciences</topic><topic>Membrane Potentials - drug effects</topic><topic>Membrane Potentials - physiology</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Neurons - physiology</topic><topic>Organometallic Compounds - administration & dosage</topic><topic>Organometallic Compounds - chemistry</topic><topic>Organometallic Compounds - pharmacokinetics</topic><topic>Oxidation-Reduction</topic><topic>Pharmacology. Drug treatments</topic><topic>Photochemistry</topic><topic>Potassium Channel Blockers - administration & dosage</topic><topic>Potassium Channel Blockers - chemistry</topic><topic>Potassium Channel Blockers - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zayat, Leonardo</creatorcontrib><creatorcontrib>Calero, Cecilia</creatorcontrib><creatorcontrib>Alborés, Pablo</creatorcontrib><creatorcontrib>Baraldo, Luis</creatorcontrib><creatorcontrib>Etchenique, Roberto</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zayat, Leonardo</au><au>Calero, Cecilia</au><au>Alborés, Pablo</au><au>Baraldo, Luis</au><au>Etchenique, Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A New Strategy for Neurochemical Photodelivery: Metal−Ligand Heterolytic Cleavage</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2003-01-29</date><risdate>2003</risdate><volume>125</volume><issue>4</issue><spage>882</spage><epage>883</epage><pages>882-883</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><coden>JACSAT</coden><abstract>A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal−ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>12537482</pmid><doi>10.1021/ja0278943</doi><tpages>2</tpages></addata></record> |
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| subjects | 2,2'-Dipyridyl - administration & dosage 2,2'-Dipyridyl - analogs & derivatives 2,2'-Dipyridyl - chemistry 2,2'-Dipyridyl - pharmacokinetics 4-Aminopyridine - administration & dosage 4-Aminopyridine - chemistry 4-Aminopyridine - pharmacokinetics Action Potentials - drug effects Action Potentials - physiology Analysis Animals Biological and medical sciences Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Carriers - pharmacokinetics Ganglia - cytology Ganglia - metabolism Ganglia - physiology General pharmacology Leeches Medical sciences Membrane Potentials - drug effects Membrane Potentials - physiology Neurons - drug effects Neurons - metabolism Neurons - physiology Organometallic Compounds - administration & dosage Organometallic Compounds - chemistry Organometallic Compounds - pharmacokinetics Oxidation-Reduction Pharmacology. Drug treatments Photochemistry Potassium Channel Blockers - administration & dosage Potassium Channel Blockers - chemistry Potassium Channel Blockers - pharmacokinetics |
| title | A New Strategy for Neurochemical Photodelivery: Metal−Ligand Heterolytic Cleavage |
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