A New Strategy for Neurochemical Photodelivery: Metal−Ligand Heterolytic Cleavage

A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal−ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule i...

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Veröffentlicht in:	Journal of the American Chemical Society 2003-01, Vol.125 (4), p.882-883
Hauptverfasser:	Zayat, Leonardo, Calero, Cecilia, Alborés, Pablo, Baraldo, Luis, Etchenique, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2'-Dipyridyl - administration & dosage 2,2'-Dipyridyl - analogs & derivatives 2,2'-Dipyridyl - chemistry 2,2'-Dipyridyl - pharmacokinetics 4-Aminopyridine - administration & dosage 4-Aminopyridine - chemistry 4-Aminopyridine - pharmacokinetics Action Potentials - drug effects Action Potentials - physiology Analysis Animals Biological and medical sciences Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Carriers - pharmacokinetics Ganglia - cytology Ganglia - metabolism Ganglia - physiology General pharmacology Leeches Medical sciences Membrane Potentials - drug effects Membrane Potentials - physiology Neurons - drug effects Neurons - metabolism Neurons - physiology Organometallic Compounds - administration & dosage Organometallic Compounds - chemistry Organometallic Compounds - pharmacokinetics Oxidation-Reduction Pharmacology. Drug treatments Photochemistry Potassium Channel Blockers - administration & dosage Potassium Channel Blockers - chemistry Potassium Channel Blockers - pharmacokinetics
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Beschreibung
Zusammenfassung:	A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal−ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja0278943