Adiponectin and protection against type 2 diabetes mellitus

Adiponectin is an adipocyte-derived peptide, which has antiinflammatory and insulin-sensitising properties. We designed a nested case-control study to assess whether baseline adiponectin concentrations in plasma are independently associated with risk of type 2 diabetes. We found that adiponectin con...

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Veröffentlicht in:	The Lancet (British edition) 2003-01, Vol.361 (9353), p.226-228
Hauptverfasser:	Spranger, Joachim, Kroke, Anja, Möhlig, Matthias, Bergmann, Manuela M, Ristow, Michael, Boeing, Heiner, Pfeiffer, Andreas FH
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Adult Aged Alcoholic beverages Biological and medical sciences Body Constitution Body Mass Index Case-Control Studies Data collection Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - etiology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Exercise Female Genetics Health risk assessment Hemoglobin Hip Humans Insulin Intercellular Signaling Peptides and Proteins Male Medical sciences Middle Aged Pathogenesis Peptides Proteins - genetics Proteins - isolation & purification Ratios Risk Risk Factors Risk reduction Sex ratio Smoking Software Statistical analysis Surveys and Questionnaires Writing
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Zusammenfassung:	Adiponectin is an adipocyte-derived peptide, which has antiinflammatory and insulin-sensitising properties. We designed a nested case-control study to assess whether baseline adiponectin concentrations in plasma are independently associated with risk of type 2 diabetes. We found that adiponectin concentrations in plasma were lower among individuals who later developed type 2 diabetes than among controls (mean 5·34 μg/mL [SD 3·49] vs 6·87 μg/mL [4·58], p
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(03)12255-6