Toxin-Antitoxin Pairs in Bacteria: Killers or Stress Regulators?

Plasmid toxin-antitoxin systems, which kill daughter cells that fail to inherit the plasmid genome, have chromosomal homologs in eubacteria and archaea. In this issue of Cell, Pederson et al. show that the E. coli RelE toxin cleaves mRNA in the ribosomal A site, potentially allowing it to function a...

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Veröffentlicht in:	Cell 2003-01, Vol.112 (1), p.2-4
Hauptverfasser:	Hayes, Christopher S., Sauer, Robert T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitoxins - genetics Bacteria - genetics Bacterial Toxins - genetics Escherichia coli Proteins - genetics Gene Expression Regulation, Bacterial Genes, Bacterial Heat-Shock Proteins - biosynthesis Operon Plasmids - genetics Protein Biosynthesis Ribosomes - metabolism RNA, Messenger - metabolism Transcription, Genetic
Online-Zugang:	Volltext
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Zusammenfassung:	Plasmid toxin-antitoxin systems, which kill daughter cells that fail to inherit the plasmid genome, have chromosomal homologs in eubacteria and archaea. In this issue of Cell, Pederson et al. show that the E. coli RelE toxin cleaves mRNA in the ribosomal A site, potentially allowing it to function as a stress regulator during amino acid starvation.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/S0092-8674(02)01282-5