Chromosomal abnormalities in relation to clinical disease in patients with cutaneous T-cell lymphoma: a 5-year follow-up study

Summary Background Patients with cutaneous T‐cell lymphoma (CTCL) show chromosomal aberrations in skin and blood lymphocytes. Objectives To evaluate the significance of peripheral blood clonal or non‐clonal chromosomal abnormalities in comparison with the clinical course of cutaneous T‐cell lymphoma patients. Patients/methods Five patients with large‐plaque parapsoriasis (LPP) or with follicular mucinosis, eight with mycosis fungoides and two with Sézary syndrome were followed for an average of 54 months. G‐banding and enzyme‐detected in situ hybridization (EDISH) were used to identify aberrations in chromosomes 1, 6, 8, 9, 11, 13/21, 15 or 17, that had previously showed frequent aberrations. Results The aberration rates of all chromosomes studied differed between patients with active disease and healthy or photochemotherapy‐treated controls by EDISH or G‐banding (P