Aggressive “Breast-like” Adenocarcinoma of Vulva

A case o f vulvar adenocarcinoma seen in a 42-year-old woman is reported. The tumor involved the right labium majus and diffusely spread into the surrounding soft tissues as well as the inguinal lymph nodes and was histologically composed o f nests, cords, and tubular formations recalling an aggressive duct carcinoma o f breast. Likewise, tumor cells exhibited positivity for common breast tumor markers, such as epithelial membrane antigen, carcinoembryonic antigen, and glandular keratins. The possible origin o f the neoplasm from mammary ecto pic tissue in vulva or from vulvar skin adnexa is briefly discussed.