Naucleamides A—E, New Monoterpene Indole Alkaloids from Nauclea latifolia

Five new monoterpene indole alkaloids, naucleamides A—E (1—5), were isolated from the bark and wood of Nauclea latifolia, and the structures and relative stereochemistry were elucidated from the spectroscopic data. Naucleamide E (5) is a unique monoterpene indole alkaloid possessing a pentacyclic ri...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2003, Vol.51(1), pp.58-61
Hauptverfasser:	Shigemori, Hideyuki, Kagata, Toshinori, Ishiyama, Haruaki, Morah, Frank, Ohsaki, Ayumi, Kobayashi, Jun'ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - isolation & purification amino acetal bridge Biological and medical sciences General pharmacology Indole Alkaloids - chemistry Indole Alkaloids - isolation & purification Medical sciences monoterpene indole alkaloid Monoterpenes - chemistry Monoterpenes - isolation & purification Nauclea latifolia naucleamide Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Bark - chemistry Plant Extracts - chemistry Plant Extracts - isolation & purification Rubiaceae - chemistry spectroscopic data
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Beschreibung
Zusammenfassung:	Five new monoterpene indole alkaloids, naucleamides A—E (1—5), were isolated from the bark and wood of Nauclea latifolia, and the structures and relative stereochemistry were elucidated from the spectroscopic data. Naucleamide E (5) is a unique monoterpene indole alkaloid possessing a pentacyclic ring system with an amino acetal bridge.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.51.58