Development of IgM Antibody to Group B Streptococcus Type III in Human Infants

An ELISA was developed to measure IgM antibody to albumin-coupled native capsular polysaccharide of type III group B streptococcus (GBS). The assay was standardized by two doublelabel methods that agreed within 33%. In quantitative assays, the range of IgM antibody to type III GBS in the sera of94 a...

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Veröffentlicht in:	The Journal of infectious diseases 1992-06, Vol.165 (6), p.1049-1055
Hauptverfasser:	Boyer, Kenneth M., Klegerman, Melvin E., Gotoff, Samuel P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Aging - immunology Animals Animals, Newborn Antibodies Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - blood Antigens Bacterial diseases Biological and medical sciences Enzyme linked immunosorbent assay Female Fetal Blood - immunology Human bacterial diseases Humans Immunization, Passive Immunoglobulin G - blood Immunoglobulin M - biosynthesis Immunoglobulin M - blood Immunology Infant Infant, Newborn Infants Infections Infectious Diseases Life Sciences & Biomedicine Major Articles Medical sciences Microbiology Miscellaneous Monoclonal antibodies Newborns Polysaccharides Pregnancy - blood Pregnancy - immunology Rats Rats, Inbred Strains Science & Technology Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus agalactiae Streptococcus agalactiae - immunology
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Beschreibung
Zusammenfassung:	An ELISA was developed to measure IgM antibody to albumin-coupled native capsular polysaccharide of type III group B streptococcus (GBS). The assay was standardized by two doublelabel methods that agreed within 33%. In quantitative assays, the range of IgM antibody to type III GBS in the sera of94 adult pregnant women was 1.2–50.6 µg/ml (median, 5.4), while each of 38 cord serum samples contained 7 months of age. The acquisition of specific IgM antibody is inversely correlated with the age-limited incidence of type III GBS infections in young children.
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/165.6.1049