Full-length cDNA sequence of dengue type 1 virus (Singapore strain S275/90)

The complete nucleotide sequence and the deduced amino acid sequence of the genome of dengue virus type 1 (Singapore strain S275/90) were determined from cDNA clones. The single-stranded, positive-sense RNA is 10,718 nucleotides in length and contains a single long open reading frame of 10,188 nucle...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1992-06, Vol.188 (2), p.953-958
Hauptverfasser:	Fu, Jianlin, Tan, Boon-Huan, Yap, Eu-Hian, Chan, Yow-Cheong, Tan, Y.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Composition Base Sequence Biological and medical sciences Dengue Virus - genetics dengue virus 1 DNA - genetics Fundamental and applied biological sciences. Psychology Genes. Genome Molecular and cellular biology Molecular genetics Molecular Sequence Data Oligodeoxyribonucleotides - chemistry Sequence Homology, Nucleic Acid Species Specificity
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Beschreibung
Zusammenfassung:	The complete nucleotide sequence and the deduced amino acid sequence of the genome of dengue virus type 1 (Singapore strain S275/90) were determined from cDNA clones. The single-stranded, positive-sense RNA is 10,718 nucleotides in length and contains a single long open reading frame of 10,188 nucleotides encoding a polyprotein of 3396 amino acids. The genomic size and organization were found to be similar to that of other dengue virus serotypes. Both the nucleotide and deduced amino acid sequences were compared with the partial sequence of DEN1 (Nauru Island) and complete sequences of DEN2 (Jamaica), DEN3 (H87), and DEN4 (Dominica) virus genomes.
ISSN:	0042-6822 1096-0341
DOI:	10.1016/0042-6822(92)90560-C