Prevention of Haemophilus influenzae Type b Infections in Apache and Navajo Children

Prospective surveillance of Haemophilus influenzae type b (Hib) disease has been done since 1981 in two high-risk populations, White Mountain Apaches and Navajos. The attack rate in children 90% efficacious in protecting Navajo infants from Hib disease when given at 2 and 4 months of age. Even a sin...

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Veröffentlicht in:	The Journal of infectious diseases 1992-06, Vol.165, p.S144-S151
Hauptverfasser:	Santosham, Mathuram, Rivin, Beth, Wolff, Mark, Reid, Raymond, Newcomer, Wendy, Letson, G. William, Almeido-Hill, Janné, Thompson, Claudette, Siber, George R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - blood Bacterial Capsules Bacterial Outer Membrane Proteins - adverse effects Bacterial Outer Membrane Proteins - immunology Bacterial Proteins - adverse effects Bacterial Proteins - immunology Bacterial Vaccines - adverse effects Bacterial Vaccines - immunology Child, Preschool Children Cohort Studies Conjugate vaccines Dosage Dose response relationship Dose-Response Relationship, Immunologic Epidemiology Female Haemophilus Infections - epidemiology Haemophilus Infections - prevention & control Haemophilus influenzae - immunology Haemophilus influenzae type b Haemophilus Vaccines Humans Incidence Indians, North American Infant Infants Male Meningitis, Haemophilus - epidemiology Meningitis, Haemophilus - prevention & control Polysaccharides Polysaccharides, Bacterial - adverse effects Polysaccharides, Bacterial - immunology Retrospective Studies Session IV: Prevention of Haemophilus influenzae Type b Disease by Vaccination Vaccination Vaccines, Synthetic - immunology
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Beschreibung
Zusammenfassung:	Prospective surveillance of Haemophilus influenzae type b (Hib) disease has been done since 1981 in two high-risk populations, White Mountain Apaches and Navajos. The attack rate in children 90% efficacious in protecting Navajo infants from Hib disease when given at 2 and 4 months of age. Even a single dose achieved a high protective efficacy.
ISSN:	0022-1899
DOI:	10.1093/infdis/165-Supplement_1-S144