Norepinephrine amplifies effects of vasopressin on the isolated rat heart
We compared effects of perfusion of norepinephrine (NE, 10 −9 mol 1 −1) and of unchanged Krebs-Henseleit solution on the cardiac response to bolus injection of arginine vasopressin (AVP, 2 ng). 14 isolated rat working heart preparations were used in a balanced cross-over design. Coronary flow, oxyge...
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| Veröffentlicht in: | Regulatory peptides 1992-04, Vol.39 (1), p.35-41 |
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| creator | Derad, Inge Pauschinger, Peter Born, Jan |
| description | We compared effects of perfusion of norepinephrine (NE, 10
−9 mol 1
−1) and of unchanged Krebs-Henseleit solution on the cardiac response to bolus injection of arginine vasopressin (AVP, 2 ng). 14 isolated rat working heart preparations were used in a balanced cross-over design. Coronary flow, oxygen consumption and extraction, heart rate and total flow were continuously recorded. The concentration of NE was below that exerting per se systematic influences on cardiac activity. However, NE changed the cardiac response to AVP: (1) the AVP-induced reduction in coronary flow was greater during NE (mean: 41.7%) than vehicle perfusion (30.5%,
P |
| doi_str_mv | 10.1016/0167-0115(92)90006-G |
| format | Article |
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−9 mol 1
−1) and of unchanged Krebs-Henseleit solution on the cardiac response to bolus injection of arginine vasopressin (AVP, 2 ng). 14 isolated rat working heart preparations were used in a balanced cross-over design. Coronary flow, oxygen consumption and extraction, heart rate and total flow were continuously recorded. The concentration of NE was below that exerting per se systematic influences on cardiac activity. However, NE changed the cardiac response to AVP: (1) the AVP-induced reduction in coronary flow was greater during NE (mean: 41.7%) than vehicle perfusion (30.5%,
P<0.005). (2) The AVP-induced decrease in oxygen consumption was stronger on top of the NE (41.5%) than vehicle perfusion (33.6%,
P<0.005). (3) Following AVP, oxygen extraction during NE was increased compared to oxygen extraction during vehicle perfusion (3.61 ± 0.03 vs. 3.46 ± 0.02 μl O
2 ml
−1 g
−1,
P<0.005). Results support the view of a potentiating role of catecholamines for direct cardiovascular effects of AVP.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/0167-0115(92)90006-G</identifier><identifier>PMID: 1579658</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Arginine Vasopressin - pharmacology ; Arginine-vasopressin ; Biological and medical sciences ; Cardiac activity ; Coronary constriction ; Fundamental and applied biological sciences. Psychology ; Heart ; Heart - drug effects ; In Vitro Techniques ; Isolated working heart ; Male ; Norepinephrine ; Norepinephrine - pharmacology ; Perfusion ; Rats ; Rats, Inbred Strains ; Vertebrates: cardiovascular system</subject><ispartof>Regulatory peptides, 1992-04, Vol.39 (1), p.35-41</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c335t-d0d3abf0f75773a399ce34c6600d35f4bf839a06e0f82fe54698e763aac94b8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/016701159290006G$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5250108$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1579658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Derad, Inge</creatorcontrib><creatorcontrib>Pauschinger, Peter</creatorcontrib><creatorcontrib>Born, Jan</creatorcontrib><title>Norepinephrine amplifies effects of vasopressin on the isolated rat heart</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>We compared effects of perfusion of norepinephrine (NE, 10
−9 mol 1
−1) and of unchanged Krebs-Henseleit solution on the cardiac response to bolus injection of arginine vasopressin (AVP, 2 ng). 14 isolated rat working heart preparations were used in a balanced cross-over design. Coronary flow, oxygen consumption and extraction, heart rate and total flow were continuously recorded. The concentration of NE was below that exerting per se systematic influences on cardiac activity. However, NE changed the cardiac response to AVP: (1) the AVP-induced reduction in coronary flow was greater during NE (mean: 41.7%) than vehicle perfusion (30.5%,
P<0.005). (2) The AVP-induced decrease in oxygen consumption was stronger on top of the NE (41.5%) than vehicle perfusion (33.6%,
P<0.005). (3) Following AVP, oxygen extraction during NE was increased compared to oxygen extraction during vehicle perfusion (3.61 ± 0.03 vs. 3.46 ± 0.02 μl O
2 ml
−1 g
−1,
P<0.005). Results support the view of a potentiating role of catecholamines for direct cardiovascular effects of AVP.</description><subject>Animals</subject><subject>Arginine Vasopressin - pharmacology</subject><subject>Arginine-vasopressin</subject><subject>Biological and medical sciences</subject><subject>Cardiac activity</subject><subject>Coronary constriction</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart</subject><subject>Heart - drug effects</subject><subject>In Vitro Techniques</subject><subject>Isolated working heart</subject><subject>Male</subject><subject>Norepinephrine</subject><subject>Norepinephrine - pharmacology</subject><subject>Perfusion</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: cardiovascular system</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFKxDAQhoMouq6-gUIOInqoJk2bNhdBRNcF0YueQzadsJFuUzNdwbc3dRe9eZiZw__NMHyEnHB2xRmX16mqjHFeXqj8UjHGZDbbIRNeVyLjspa7ZPKLHJBDxHfGeFlVYp_sp6lkWU_I_DlE6H0H_TKmTs2qb73zgBScAzsgDY5-Ggx9BETf0dDRYQnUY2jNAA2NZqBLMHE4InvOtAjH2zklbw_3r3eP2dPLbH53-5RZIcoha1gjzMIxV42vGKGUBVFYKVkKSlcsXC2UYRKYq3MHZSFVDZUUxlhVLGonpuR8c7eP4WMNOOiVRwttazoIa9RVrgpeVCKBxQa0MSBGcLqPfmXil-ZMjwb1qEePerTK9Y9BPUtrp9v768UKmr-ljbKUn21zg9a0LprOevzFyrxknI3YzQaD5OLTQ9RoPXQWGh-TV90E__8f36sKjNc</recordid><startdate>19920429</startdate><enddate>19920429</enddate><creator>Derad, Inge</creator><creator>Pauschinger, Peter</creator><creator>Born, Jan</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920429</creationdate><title>Norepinephrine amplifies effects of vasopressin on the isolated rat heart</title><author>Derad, Inge ; Pauschinger, Peter ; Born, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-d0d3abf0f75773a399ce34c6600d35f4bf839a06e0f82fe54698e763aac94b8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Arginine Vasopressin - pharmacology</topic><topic>Arginine-vasopressin</topic><topic>Biological and medical sciences</topic><topic>Cardiac activity</topic><topic>Coronary constriction</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart</topic><topic>Heart - drug effects</topic><topic>In Vitro Techniques</topic><topic>Isolated working heart</topic><topic>Male</topic><topic>Norepinephrine</topic><topic>Norepinephrine - pharmacology</topic><topic>Perfusion</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Derad, Inge</creatorcontrib><creatorcontrib>Pauschinger, Peter</creatorcontrib><creatorcontrib>Born, Jan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Derad, Inge</au><au>Pauschinger, Peter</au><au>Born, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Norepinephrine amplifies effects of vasopressin on the isolated rat heart</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>1992-04-29</date><risdate>1992</risdate><volume>39</volume><issue>1</issue><spage>35</spage><epage>41</epage><pages>35-41</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>We compared effects of perfusion of norepinephrine (NE, 10
−9 mol 1
−1) and of unchanged Krebs-Henseleit solution on the cardiac response to bolus injection of arginine vasopressin (AVP, 2 ng). 14 isolated rat working heart preparations were used in a balanced cross-over design. Coronary flow, oxygen consumption and extraction, heart rate and total flow were continuously recorded. The concentration of NE was below that exerting per se systematic influences on cardiac activity. However, NE changed the cardiac response to AVP: (1) the AVP-induced reduction in coronary flow was greater during NE (mean: 41.7%) than vehicle perfusion (30.5%,
P<0.005). (2) The AVP-induced decrease in oxygen consumption was stronger on top of the NE (41.5%) than vehicle perfusion (33.6%,
P<0.005). (3) Following AVP, oxygen extraction during NE was increased compared to oxygen extraction during vehicle perfusion (3.61 ± 0.03 vs. 3.46 ± 0.02 μl O
2 ml
−1 g
−1,
P<0.005). Results support the view of a potentiating role of catecholamines for direct cardiovascular effects of AVP.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1579658</pmid><doi>10.1016/0167-0115(92)90006-G</doi><tpages>7</tpages></addata></record> |
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| ispartof | Regulatory peptides, 1992-04, Vol.39 (1), p.35-41 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Arginine Vasopressin - pharmacology Arginine-vasopressin Biological and medical sciences Cardiac activity Coronary constriction Fundamental and applied biological sciences. Psychology Heart Heart - drug effects In Vitro Techniques Isolated working heart Male Norepinephrine Norepinephrine - pharmacology Perfusion Rats Rats, Inbred Strains Vertebrates: cardiovascular system |
| title | Norepinephrine amplifies effects of vasopressin on the isolated rat heart |
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