Norepinephrine amplifies effects of vasopressin on the isolated rat heart

We compared effects of perfusion of norepinephrine (NE, 10 −9 mol 1 −1) and of unchanged Krebs-Henseleit solution on the cardiac response to bolus injection of arginine vasopressin (AVP, 2 ng). 14 isolated rat working heart preparations were used in a balanced cross-over design. Coronary flow, oxyge...

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Veröffentlicht in:	Regulatory peptides 1992-04, Vol.39 (1), p.35-41
Hauptverfasser:	Derad, Inge, Pauschinger, Peter, Born, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine Vasopressin - pharmacology Arginine-vasopressin Biological and medical sciences Cardiac activity Coronary constriction Fundamental and applied biological sciences. Psychology Heart Heart - drug effects In Vitro Techniques Isolated working heart Male Norepinephrine Norepinephrine - pharmacology Perfusion Rats Rats, Inbred Strains Vertebrates: cardiovascular system
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Zusammenfassung:	We compared effects of perfusion of norepinephrine (NE, 10 −9 mol 1 −1) and of unchanged Krebs-Henseleit solution on the cardiac response to bolus injection of arginine vasopressin (AVP, 2 ng). 14 isolated rat working heart preparations were used in a balanced cross-over design. Coronary flow, oxygen consumption and extraction, heart rate and total flow were continuously recorded. The concentration of NE was below that exerting per se systematic influences on cardiac activity. However, NE changed the cardiac response to AVP: (1) the AVP-induced reduction in coronary flow was greater during NE (mean: 41.7%) than vehicle perfusion (30.5%, P
ISSN:	0167-0115 1873-1686
DOI:	10.1016/0167-0115(92)90006-G