Diabetic Pregnancy: Evidence of Selection on the Rh Blood Group System

The blood glucose levels of pregnant women with insulin-dependent diabetes mellitus and the blood glucose levels of newborns during the first few hours of life show an association with maternal Rh genotype. Distortions of joint maternal-fetal Rh phenotype distribution have also been observed. Becaus...

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Veröffentlicht in:	Human biology 1992-02, Vol.64 (1), p.81-87
Hauptverfasser:	GLORIA-BOTTINI, F., GERLINI, G., AMANTE, A., PASCONE, R., BOTTINI, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blood glucose Blood Glucose - analysis Blood sugar Diabetes Diabetes complications Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - genetics Diabetes research Diseases Female Fundamental and applied biological sciences. Psychology Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Genotype Haplotypes Human Humans Hypoglycemia Hypoglycemia - epidemiology Infant, Newborn Phenotype Phenotypes Population genetics, reproduction patterns Pregnancy Pregnancy in diabetics Pregnancy in Diabetics - blood Pregnancy in Diabetics - epidemiology Pregnancy in Diabetics - genetics Pregnant women Rh factor Rh-Hr Blood-Group System - genetics Rome - epidemiology Selection, Genetic Type 1 diabetes mellitus Type 2 diabetes mellitus Women
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Zusammenfassung:	The blood glucose levels of pregnant women with insulin-dependent diabetes mellitus and the blood glucose levels of newborns during the first few hours of life show an association with maternal Rh genotype. Distortions of joint maternal-fetal Rh phenotype distribution have also been observed. Because a cluster of genes involved in glycide metabolism is located on the short arm of chromosome 1, the present observations may reflect the action of these genes.
ISSN:	0018-7143 1534-6617