Profound Steric Control of Reactivity in Aryl Halide Addition to Bisphosphane Palladium(0) Complexes

Profound Steric Control of Reactivity in Aryl Halide Addition to Bisphosphane Palladium(0) Complexes

The steric bulk of the phosphane ligand determines the mechanism of the ArX addition to zero‐valent [PdL2] complexes. This effect has been studied by variation of ligands (catalyst: [Pd(PCxntBu3−n)2]; n=0–3, Cx=cyclohexyl) in Pd couplings of unsaturated electrophiles, and different reaction pathways...

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Veröffentlicht in:Angewandte Chemie International Edition 2002-05, Vol.41 (10), p.1760-1763
Hauptverfasser: Galardon, Erwan, Ramdeehul, Shailesh, Brown, John M., Cowley, Andrew, Hii, King Kuok (Mimi), Jutand, Anny
Format: Artikel
Sprache:eng
Schlagworte:
cross-coupling
palladium
phosphane ligands
reaction mechanisms
steric hindrance
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Zusammenfassung:The steric bulk of the phosphane ligand determines the mechanism of the ArX addition to zero‐valent [PdL2] complexes. This effect has been studied by variation of ligands (catalyst: [Pd(PCxntBu3−n)2]; n=0–3, Cx=cyclohexyl) in Pd couplings of unsaturated electrophiles, and different reaction pathways (A=associative, B=dissociative) identified, depending on the size of the ligand.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20020517)41:10<1760::AID-ANIE1760>3.0.CO;2-3