Samarium Diiodide-Induced Reductive Cross-Coupling of Nitrones with Aldehydes and Ketones

Samarium Diiodide-Induced Reductive Cross-Coupling of Nitrones with Aldehydes and Ketones

Highly substituted amino alcohols or N‐hydroxyamino alcohols can be prepared in good yield through a novel reductive cross‐coupling of nitrones with aldehydes or ketones (see scheme). The reactions are fast and highly chemoselective, that is, no homocoupling or reduction products are formed.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2002-05, Vol.41 (10), p.1772-1775
Hauptverfasser: Masson, Géraldine, Py, Sandrine, Vallée, Yannick
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols - chemistry
Aldehydes - chemistry
amino alcohols
Carbon - chemistry
cross-coupling
C−C coupling
Electron Spin Resonance Spectroscopy
Free Radicals
Hempa - chemistry
Iodides - chemistry
Ketones - chemistry
Models, Chemical
Nitrogen - chemistry
Nitrogen Oxides - chemistry
nitrones
Organic Chemicals - chemistry
Oxygen - chemistry
samarium
Samarium - chemistry
Time Factors
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Beschreibung
Zusammenfassung:Highly substituted amino alcohols or N‐hydroxyamino alcohols can be prepared in good yield through a novel reductive cross‐coupling of nitrones with aldehydes or ketones (see scheme). The reactions are fast and highly chemoselective, that is, no homocoupling or reduction products are formed.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20020517)41:10<1772::AID-ANIE1772>3.0.CO;2-Q