Polymorphism of MDR1 Gene in Healthy Japanese Subjects: A Novel SNP with an Amino Acid Substitution (Glu108Lys)

Polymorphism of MDR1 Gene in Healthy Japanese Subjects: A Novel SNP with an Amino Acid Substitution (Glu108Lys)

We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P-glycoprotein (MDR1); ACCESSION NUMBER, M29427; LENGTH, 25...

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Veröffentlicht in:Drug metabolism and pharmacokinetics 2002, Vol.17 (5), p.479-481
Hauptverfasser: Honda, Tomohiro, Dan, Yukihiko, Koyabu, Noriko, Ieiri, Ichiro, Otsubo, Kenji, Higuchi, Shun, Ohtani, Hisakazu, Sawada, Yasufumi
Format: Artikel
Sprache:eng
Schlagworte:
amino acid substitution
exon 5
G325A
multidrug-resistance 1 (P-glycoprotein MDR1, ABCB1)
single nucleotide polymorphism (SNP)
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Zusammenfassung:We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P-glycoprotein (MDR1); ACCESSION NUMBER, M29427; LENGTH, 25 bases; 5′-ATGAATCTGGAGG/AAAGACATGACCA-3′. This SNP is expected to cause an amino acid substitution (Glu108Lys). In this study, one homozygote and one heterozygote for G325A were identified.
ISSN:1347-4367
1880-0920
DOI:10.2133/dmpk.17.479