Additional RFLPs at D10S94 and the Development of PCR-based variant detection systems: Implications for disease genotype prediction in MEN 2A, MEN 2B, and MTC1 families

We report the identification of two new RELPs and the development of PCR primer pairs for amplification and detection of D10S94 polymorphisms. These new variants and the conversion of two RELPs to PCR marker systems will be of value in MEN 2A, MEN 2B, and MTC1 disease screening programs and in the c...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1992-05, Vol.13 (1), p.233-234
Hauptverfasser:	Brooks-Wilson, Angela R., Smailus, Duene, Gilchrist, Dawna, Goodfellow, Paul J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences carcinoma Carcinoma - genetics Chromosomes, Human, Pair 10 D10S94 locus Endocrinopathies Endodeoxyribonucleases - metabolism Genetic Testing Genotype genotypes Humans loci Malignant tumors man Medical sciences Molecular Sequence Data multiple endocrine neoplasia Multiple Endocrine Neoplasia - genetics Oligodeoxyribonucleotides - genetics Polymerase Chain Reaction Polymorphism, Restriction Fragment Length restriction fragment length polymorphism thyroid Thyroid Neoplasms - genetics Thyroid. Thyroid axis (diseases)
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Zusammenfassung:	We report the identification of two new RELPs and the development of PCR primer pairs for amplification and detection of D10S94 polymorphisms. These new variants and the conversion of two RELPs to PCR marker systems will be of value in MEN 2A, MEN 2B, and MTC1 disease screening programs and in the continued development of the linkage and physical maps of proximal 10q.
ISSN:	0888-7543 1089-8646
DOI:	10.1016/0888-7543(92)90231-G