Quantifying drug-induced changes in Parkinsonian rigidity using an instrumental measure of activated stiffness

We review the literature on quantifying parkinsonian rigidity and present data from 124 subjects to demonstrate the clinical utility of activated stiffness to model rigidity. This method eliminates many of the confounding variables associated with the subjective assessment of rigidity. This 5-min co...

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Veröffentlicht in:	Clinical neuropharmacology 1992-02, Vol.15 (1), p.1-12
Hauptverfasser:	CALIGIURI, M. P, GALASKO, D. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anticonvulsants. Antiepileptics. Antiparkinson agents Antiparkinson Agents - therapeutic use Biological and medical sciences Female Humans Male Medical sciences Middle Aged Models, Biological Muscle Rigidity - diagnosis Muscle Rigidity - drug therapy Muscle Rigidity - physiopathology Neuropharmacology Parkinson Disease - diagnosis Parkinson Disease - drug therapy Parkinson Disease - physiopathology Pharmacology. Drug treatments
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Zusammenfassung:	We review the literature on quantifying parkinsonian rigidity and present data from 124 subjects to demonstrate the clinical utility of activated stiffness to model rigidity. This method eliminates many of the confounding variables associated with the subjective assessment of rigidity. This 5-min computer-assisted procedure was highly reliable and sensitive to pharmacologic influences that produce and reduce parkinsonian rigidity.
ISSN:	0362-5664 1537-162X
DOI:	10.1097/00002826-199202000-00001