Studies on Uricosuric Diuretics. III. Substituted 1, 3-Dioxolo[4, 5-f]-1, 2-benzisoxazole-6-carboxylic Acids and 1, 3-Dioxolo[4, 5-g]-1, 2-benzisoxazole-7-carboxylic Acids

A series of substituted 1, 3-dioxolo[4, 5-f]-1, 2-benzisoxazole-6-carboxylic acids 13 and 1, 3-dioxolo[4, 5-g]-1, 2-benzisozazole-7-carboxylic acids 14 were synthesized and evaluated for diuretic and uricosuric activities in rats. Most of the benzisoxazole derivatives 13 and 14 showed potent diureti...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1992/01/25, Vol.40(1), pp.109-116
Hauptverfasser:	SATO, Haruhiko, DAN, Takashi, ONUMA, Etsuro, TANAKA, Haruko, AOKI, Bunya, KOGA, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	1, 3-dioxolo[4, 5-f]-1, 2-benzisoxazole-6-carboxylic acid 1, 3-dioxolo[4, 5-g]-1, 2-benzisoxazole-7-carboxylic acid Animals Chemistry Dioxoles - chemical synthesis Dioxoles - pharmacology diuretic activity Diuretics - chemical synthesis Diuretics - pharmacology Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms In Vitro Techniques Isoxazoles - chemical synthesis Isoxazoles - pharmacology Male Mice Organic chemistry Preparations and properties Rats Rats, Inbred Strains uricosuric activity Uricosuric Agents - chemical synthesis Uricosuric Agents - pharmacology
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Zusammenfassung:	A series of substituted 1, 3-dioxolo[4, 5-f]-1, 2-benzisoxazole-6-carboxylic acids 13 and 1, 3-dioxolo[4, 5-g]-1, 2-benzisozazole-7-carboxylic acids 14 were synthesized and evaluated for diuretic and uricosuric activities in rats. Most of the benzisoxazole derivatives 13 and 14 showed potent diuretic activities. Moderate uricosuric activities were also found in 14a, 14b, and 14f.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.40.109