The human complex I NDUFS4 subunit: from gene structure to function and pathology

The human complex I NDUFS4 subunit: from gene structure to function and pathology

Complex I is the first and largest enzyme of the oxidative phosphorylation system. It consists of at least 43 subunits. Recent studies have shown that the NDUFS4 subunit of complex I contributes to the activation of the complex through cAMP dependent phosphorylation of a conserved site (RVS) located...

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Veröffentlicht in:Mitochondrion 2002-11, Vol.2 (1), p.109-115
Hauptverfasser: Budde, S.M.S, Heuvel, L.P.W.J.van den, Smeitink, J.A.M
Format: Artikel
Sprache:eng
Schlagworte:
Complex I
Leigh syndrome
NDUFS4
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Zusammenfassung:Complex I is the first and largest enzyme of the oxidative phosphorylation system. It consists of at least 43 subunits. Recent studies have shown that the NDUFS4 subunit of complex I contributes to the activation of the complex through cAMP dependent phosphorylation of a conserved site (RVS) located at the C-terminal region of this protein. This report focuses on the NDUFS4 subunit. Summarized is the current knowledge of this subunit, from gene structure to function and pathology.
ISSN:1567-7249
1872-8278
DOI:10.1016/S1567-7249(02)00035-1