A group of potassium-channel blockers-acetylcholine releasers : new potentials for alzheimer disease ? A review
This review of the literature examines systematically the data currently available for potassium-channel blockers to reassess their clinical potential in Alzheimer disease. The conclusion is that potassium-channel blockers may have been dismissed prematurely for the treatment of Alzheimer disease, a...
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| Veröffentlicht in: | Journal of clinical psychopharmacology 1992-04, Vol.12 (2), p.110-118 |
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| container_end_page | 118 |
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| container_issue | 2 |
| container_start_page | 110 |
| container_title | Journal of clinical psychopharmacology |
| container_volume | 12 |
| creator | LAVRETSKY, E. P JARVIK, L. F |
| description | This review of the literature examines systematically the data currently available for potassium-channel blockers to reassess their clinical potential in Alzheimer disease. The conclusion is that potassium-channel blockers may have been dismissed prematurely for the treatment of Alzheimer disease, an impression supported by data indicating intimate relationships between potassium-channel blockade and cholinergic transmission. |
| doi_str_mv | 10.1097/00004714-199204000-00006 |
| format | Article |
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The conclusion is that potassium-channel blockers may have been dismissed prematurely for the treatment of Alzheimer disease, an impression supported by data indicating intimate relationships between potassium-channel blockade and cholinergic transmission.</description><identifier>ISSN: 0271-0749</identifier><identifier>EISSN: 1533-712X</identifier><identifier>DOI: 10.1097/00004714-199204000-00006</identifier><identifier>PMID: 1573033</identifier><identifier>CODEN: JCPYDR</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Acetylcholine - metabolism ; Alzheimer Disease - drug therapy ; Alzheimer Disease - physiopathology ; Alzheimer Disease - psychology ; Biological and medical sciences ; Brain - drug effects ; Brain - physiopathology ; Central Nervous System Agents - therapeutic use ; Humans ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Potassium Channels - drug effects ; Potassium Channels - physiology ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. 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The conclusion is that potassium-channel blockers may have been dismissed prematurely for the treatment of Alzheimer disease, an impression supported by data indicating intimate relationships between potassium-channel blockade and cholinergic transmission.</description><subject>Acetylcholine - metabolism</subject><subject>Alzheimer Disease - drug therapy</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer Disease - psychology</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - physiopathology</subject><subject>Central Nervous System Agents - therapeutic use</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Potassium Channels - drug effects</subject><subject>Potassium Channels - physiology</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Receptors, Cholinergic - drug effects</subject><subject>Receptors, Cholinergic - physiology</subject><subject>Structure-Activity Relationship</subject><issn>0271-0749</issn><issn>1533-712X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1v1DAQhi0EKkvhJyD5gLgZPP6IYy5oVfElVeqFStwixxmzBide7KRV--vJsks7l9G887wz0ksIBf4OuDXv-VrKgGJgreBqndhBap6QDWgpmQHx4ynZcGGAcaPsc_Ki1l-cgzJCn5Ez0EZyKTckb-nPkpc9zYHu8-xqjcvI_M5NEybap-x_Y6nMeZzvkt_lFCekBRO6uur0A53w9mDEaY4uVRpyoS7d7zCOWOgQ6wGkH-l2Nd1EvH1JnoWVw1enfk6uP3_6fvGVXV59-XaxvWRetGpmIQy9GtD4Xjc-cK-F5UoFJzx3XLeNVU4LMXiO3ofetiC8tgBqkI3ijXHynLw93t2X_GfBOndjrB5TchPmpXZGWGgVwAq2R9CXXGvB0O1LHF2564B3h6y7_1l3D1n_k5rV-vr0Y-lHHB6Nx3DX_ZvT3lXvUihu8rE-YFpapUDJv0VXh9E</recordid><startdate>19920401</startdate><enddate>19920401</enddate><creator>LAVRETSKY, E. P</creator><creator>JARVIK, L. 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| fulltext | fulltext |
| identifier | ISSN: 0271-0749 |
| ispartof | Journal of clinical psychopharmacology, 1992-04, Vol.12 (2), p.110-118 |
| issn | 0271-0749 1533-712X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acetylcholine - metabolism Alzheimer Disease - drug therapy Alzheimer Disease - physiopathology Alzheimer Disease - psychology Biological and medical sciences Brain - drug effects Brain - physiopathology Central Nervous System Agents - therapeutic use Humans Medical sciences Neuropharmacology Pharmacology. Drug treatments Potassium Channels - drug effects Potassium Channels - physiology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptors, Cholinergic - drug effects Receptors, Cholinergic - physiology Structure-Activity Relationship |
| title | A group of potassium-channel blockers-acetylcholine releasers : new potentials for alzheimer disease ? A review |
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