A group of potassium-channel blockers-acetylcholine releasers : new potentials for alzheimer disease ? A review

This review of the literature examines systematically the data currently available for potassium-channel blockers to reassess their clinical potential in Alzheimer disease. The conclusion is that potassium-channel blockers may have been dismissed prematurely for the treatment of Alzheimer disease, a...

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Veröffentlicht in:	Journal of clinical psychopharmacology 1992-04, Vol.12 (2), p.110-118
Hauptverfasser:	LAVRETSKY, E. P, JARVIK, L. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Alzheimer Disease - drug therapy Alzheimer Disease - physiopathology Alzheimer Disease - psychology Biological and medical sciences Brain - drug effects Brain - physiopathology Central Nervous System Agents - therapeutic use Humans Medical sciences Neuropharmacology Pharmacology. Drug treatments Potassium Channels - drug effects Potassium Channels - physiology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptors, Cholinergic - drug effects Receptors, Cholinergic - physiology Structure-Activity Relationship
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Zusammenfassung:	This review of the literature examines systematically the data currently available for potassium-channel blockers to reassess their clinical potential in Alzheimer disease. The conclusion is that potassium-channel blockers may have been dismissed prematurely for the treatment of Alzheimer disease, an impression supported by data indicating intimate relationships between potassium-channel blockade and cholinergic transmission.
ISSN:	0271-0749 1533-712X
DOI:	10.1097/00004714-199204000-00006