Clozapine decreases rat brain dehydroepiandrosterone and dehydroepiandrosterone sulfate levels

We examined the influence of the atypical antipsychotic agent clozapine compared to haloperidol, on levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate ester (both γ-aminobutyric acid A (GABA A) receptor allosteric antagonists) in the rat cortex. i.p. injections of clozapine (5 and 1...

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Veröffentlicht in:	European neuropsychopharmacology 2003, Vol.13 (1), p.29-31
Hauptverfasser:	Nechmad, Allon, Maayan, Rachel, Ramadan, Edward, Morad, Oren, Poyurovsky, Michael, Weizman, Abraham
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - metabolism Brain Chemistry - drug effects Clozapine Clozapine - pharmacology Dehydroepiandosterone Dehydroepiandosterone sulphate Dehydroepiandrosterone - analysis Dehydroepiandrosterone - metabolism Dehydroepiandrosterone Sulfate - analysis Dehydroepiandrosterone Sulfate - metabolism Dopamine Antagonists - pharmacology GABA Antagonists - pharmacology Haloperidol Haloperidol - pharmacology Male Neurosteroids Rats Rats, Sprague-Dawley Receptors, GABA-A - physiology γ-Aminobutyric acid receptor
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Zusammenfassung:	We examined the influence of the atypical antipsychotic agent clozapine compared to haloperidol, on levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate ester (both γ-aminobutyric acid A (GABA A) receptor allosteric antagonists) in the rat cortex. i.p. injections of clozapine (5 and 15 mg/kg), but not haloperidol (1 mg/kg), for 8 days decreased rat brain cortical dehydroepiandrosterone and dehydroepiandrosterone sulfate levels. These findings support the role of neurosteroids and possibly GABA A receptor modulation in the mechanism of action of clozapine.
ISSN:	0924-977X 1873-7862
DOI:	10.1016/S0924-977X(02)00077-9