Preparation of [ 11C] radioligands with high specific radioactivity on a commercial PET tracer synthesizer

High specific radioactivity is required for receptor studies with PET. Hereby we wish to report our experience using Nuclear Interface PET Tracer Synthesizer for preparation of Carbon-11 radioligands and module’s modifications, which allowed to achieve high specific radioactivity.

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Bibliographische Detailangaben
Veröffentlicht in:	Nuclear medicine and biology 2003, Vol.30 (1), p.79-83
Hauptverfasser:	Matarrese, Mario, Soloviev, Dmitri, Todde, Sergio, Neutro, Felice, Petta, Pasquale, Carpinelli, Assunta, Brüssermann, Michael, Galli Kienle, Marzia, Fazio, Ferruccio
Format:	Artikel
Sprache:	eng
Schlagworte:	[ 11C]methyl iodide [ 11C]methyl triflate [ 11C]radioligands [2- 11C]acetone Biological and medical sciences Carbon Dioxide - chemistry Carbon Radioisotopes - chemistry Carbon Radioisotopes - isolation & purification Equipment Design Isotope Labeling - instrumentation Isotope Labeling - methods Ligands Medical sciences Nuclear Interface PET Tracer Quality Control Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - isolation & purification Reproducibility of Results Specific radioactivity Tomography, Emission-Computed - instrumentation Tomography, Emission-Computed - methods
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Beschreibung
Zusammenfassung:	High specific radioactivity is required for receptor studies with PET. Hereby we wish to report our experience using Nuclear Interface PET Tracer Synthesizer for preparation of Carbon-11 radioligands and module’s modifications, which allowed to achieve high specific radioactivity.
ISSN:	0969-8051 1872-9614
DOI:	10.1016/S0969-8051(02)00353-0