Glutathione Peroxidase-1 Contributes to the Neuroprotection Seen in the Superoxide Dismutase-1 Transgenic Mouse in Response to Ischemia/Reperfusion Injury
The authors hypothesized that glutathione peroxidase-1 (Gpx-1) contributes to the neuroprotection seen in the superoxide dismutase-1 transgenic (Sod-1 tg) mouse. To investigate this hypothesis, they crossed the Gpx-1 -/- mouse with the Sod-1 tg and subjected the cross to a mouse model of ischemia/re...
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| Veröffentlicht in: | Journal of cerebral blood flow and metabolism 2003-01, Vol.23 (1), p.19-22 |
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| container_title | Journal of cerebral blood flow and metabolism |
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| creator | CRACK, Peter J TAYLOR, Juliet M DE HAAN, Judy B KOLA, Ismail HERTZOG, Paul IANNELLO, Rocco C |
| description | The authors hypothesized that glutathione peroxidase-1 (Gpx-1) contributes to the neuroprotection seen in the superoxide dismutase-1 transgenic (Sod-1 tg) mouse. To investigate this hypothesis, they crossed the Gpx-1 -/- mouse with the Sod-1 tg and subjected the cross to a mouse model of ischemia/reperfusion. Two hours of focal cerebral ischemia followed by 24 hours of reperfusion was induced via intraluminal suture. The Sod-1 tg/Gpx-1 -/- cross exhibited no neuroprotection when infarct volume was measured; indeed, infarct volume increased in the Sod-1 tg/Gpx-1 -/- cross compared with the wild-type mouse. Our results suggest that Gpx-1 plays an important regulatory role in the protection of neural cells in response to ischemia/reperfusion injury. |
| doi_str_mv | 10.1097/00004647-200301000-00002 |
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To investigate this hypothesis, they crossed the Gpx-1 -/- mouse with the Sod-1 tg and subjected the cross to a mouse model of ischemia/reperfusion. Two hours of focal cerebral ischemia followed by 24 hours of reperfusion was induced via intraluminal suture. The Sod-1 tg/Gpx-1 -/- cross exhibited no neuroprotection when infarct volume was measured; indeed, infarct volume increased in the Sod-1 tg/Gpx-1 -/- cross compared with the wild-type mouse. Our results suggest that Gpx-1 plays an important regulatory role in the protection of neural cells in response to ischemia/reperfusion injury.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1097/00004647-200301000-00002</identifier><identifier>PMID: 12500087</identifier><identifier>CODEN: JCBMDN</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Biological and medical sciences ; Brain - pathology ; Brain Ischemia - enzymology ; Brain Ischemia - pathology ; Cerebral Infarction - pathology ; Glutathione Peroxidase - metabolism ; Medical sciences ; Mice ; Mice, Knockout - genetics ; Mice, Transgenic - genetics ; Neurology ; Neuroprotective Agents ; Reperfusion Injury - enzymology ; Reperfusion Injury - pathology ; Superoxide Dismutase - physiology ; Superoxide Dismutase-1 ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Journal of cerebral blood flow and metabolism, 2003-01, Vol.23 (1), p.19-22</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jan 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3037-1dc21a5f25489564b95d56229f9d39df7c8ddea4f8918f364b1cae88796db30d3</citedby><cites>FETCH-LOGICAL-c3037-1dc21a5f25489564b95d56229f9d39df7c8ddea4f8918f364b1cae88796db30d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14454740$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12500087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CRACK, Peter J</creatorcontrib><creatorcontrib>TAYLOR, Juliet M</creatorcontrib><creatorcontrib>DE HAAN, Judy B</creatorcontrib><creatorcontrib>KOLA, Ismail</creatorcontrib><creatorcontrib>HERTZOG, Paul</creatorcontrib><creatorcontrib>IANNELLO, Rocco C</creatorcontrib><title>Glutathione Peroxidase-1 Contributes to the Neuroprotection Seen in the Superoxide Dismutase-1 Transgenic Mouse in Response to Ischemia/Reperfusion Injury</title><title>Journal of cerebral blood flow and metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>The authors hypothesized that glutathione peroxidase-1 (Gpx-1) contributes to the neuroprotection seen in the superoxide dismutase-1 transgenic (Sod-1 tg) mouse. To investigate this hypothesis, they crossed the Gpx-1 -/- mouse with the Sod-1 tg and subjected the cross to a mouse model of ischemia/reperfusion. Two hours of focal cerebral ischemia followed by 24 hours of reperfusion was induced via intraluminal suture. The Sod-1 tg/Gpx-1 -/- cross exhibited no neuroprotection when infarct volume was measured; indeed, infarct volume increased in the Sod-1 tg/Gpx-1 -/- cross compared with the wild-type mouse. Our results suggest that Gpx-1 plays an important regulatory role in the protection of neural cells in response to ischemia/reperfusion injury.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain Ischemia - enzymology</subject><subject>Brain Ischemia - pathology</subject><subject>Cerebral Infarction - pathology</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Knockout - genetics</subject><subject>Mice, Transgenic - genetics</subject><subject>Neurology</subject><subject>Neuroprotective Agents</subject><subject>Reperfusion Injury - enzymology</subject><subject>Reperfusion Injury - pathology</subject><subject>Superoxide Dismutase - physiology</subject><subject>Superoxide Dismutase-1</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0271-678X</issn><issn>1559-7016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkdtu1DAURSMEokPhE0AREn0L9TW2H9FAy0jlorZIvEUe-4TxKHGmvkj0V_hanJmhlfCLfY7X3r7sqqoxeo-REueoDNYy0RCEKMKlauYWeVItMOeqEQi3T6sFIgI3rZA_T6oXMW4LISnnz6sTTPhciEX153LISaeNmzzU3yFMv53VERpcLyefglvnBLFOU502UH-FHKZdmBKYVAT1DYCvnd_v3eTdQQ31RxfHYrp3uQ3ax1_gnam_TDnCjF9D3E2-rIvtKpoNjE6fX0PR9znOviu_zeH-ZfWs10OEV8f5tPpx8el2-bm5-na5Wn64agxFVDTYGoI17wlnUvGWrRW3vCVE9cpSZXthpLWgWS8Vlj0tADYapBSqtWuKLD2tzg6-5WV3GWLqRhcNDIP2UK7cCSKl5JwU8O1_4HbKwZe7dQQrXs7HrEDyAJkwxRig73bBjTrcdxh1c3jdv_C6h_D2rdn_zdE_r0ewj8JjWgV4dwR0NHroy98aFx85xjgTDBXu9YHzOuUAD4DiClMm6V_sfq1x</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>CRACK, Peter J</creator><creator>TAYLOR, Juliet M</creator><creator>DE HAAN, Judy B</creator><creator>KOLA, Ismail</creator><creator>HERTZOG, Paul</creator><creator>IANNELLO, Rocco C</creator><general>Lippincott Williams & Wilkins</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200301</creationdate><title>Glutathione Peroxidase-1 Contributes to the Neuroprotection Seen in the Superoxide Dismutase-1 Transgenic Mouse in Response to Ischemia/Reperfusion Injury</title><author>CRACK, Peter J ; TAYLOR, Juliet M ; DE HAAN, Judy B ; KOLA, Ismail ; HERTZOG, Paul ; IANNELLO, Rocco C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3037-1dc21a5f25489564b95d56229f9d39df7c8ddea4f8918f364b1cae88796db30d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain Ischemia - enzymology</topic><topic>Brain Ischemia - pathology</topic><topic>Cerebral Infarction - pathology</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Knockout - genetics</topic><topic>Mice, Transgenic - genetics</topic><topic>Neurology</topic><topic>Neuroprotective Agents</topic><topic>Reperfusion Injury - enzymology</topic><topic>Reperfusion Injury - pathology</topic><topic>Superoxide Dismutase - physiology</topic><topic>Superoxide Dismutase-1</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CRACK, Peter J</creatorcontrib><creatorcontrib>TAYLOR, Juliet M</creatorcontrib><creatorcontrib>DE HAAN, Judy B</creatorcontrib><creatorcontrib>KOLA, Ismail</creatorcontrib><creatorcontrib>HERTZOG, Paul</creatorcontrib><creatorcontrib>IANNELLO, Rocco C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cerebral blood flow and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CRACK, Peter J</au><au>TAYLOR, Juliet M</au><au>DE HAAN, Judy B</au><au>KOLA, Ismail</au><au>HERTZOG, Paul</au><au>IANNELLO, Rocco C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione Peroxidase-1 Contributes to the Neuroprotection Seen in the Superoxide Dismutase-1 Transgenic Mouse in Response to Ischemia/Reperfusion Injury</atitle><jtitle>Journal of cerebral blood flow and metabolism</jtitle><addtitle>J Cereb Blood Flow Metab</addtitle><date>2003-01</date><risdate>2003</risdate><volume>23</volume><issue>1</issue><spage>19</spage><epage>22</epage><pages>19-22</pages><issn>0271-678X</issn><eissn>1559-7016</eissn><coden>JCBMDN</coden><abstract>The authors hypothesized that glutathione peroxidase-1 (Gpx-1) contributes to the neuroprotection seen in the superoxide dismutase-1 transgenic (Sod-1 tg) mouse. 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| ispartof | Journal of cerebral blood flow and metabolism, 2003-01, Vol.23 (1), p.19-22 |
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| subjects | Animals Biological and medical sciences Brain - pathology Brain Ischemia - enzymology Brain Ischemia - pathology Cerebral Infarction - pathology Glutathione Peroxidase - metabolism Medical sciences Mice Mice, Knockout - genetics Mice, Transgenic - genetics Neurology Neuroprotective Agents Reperfusion Injury - enzymology Reperfusion Injury - pathology Superoxide Dismutase - physiology Superoxide Dismutase-1 Vascular diseases and vascular malformations of the nervous system |
| title | Glutathione Peroxidase-1 Contributes to the Neuroprotection Seen in the Superoxide Dismutase-1 Transgenic Mouse in Response to Ischemia/Reperfusion Injury |
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