Association between blood pressure levels over time and brain atrophy in the elderly

The relation between blood pressure level and degree of global brain atrophy is equivocal. We evaluated past and present blood pressure levels and change in blood pressure over 20 years in relation to the degree of cortical atrophy on magnetic resonance imaging (MRI). In 1995–1996, we measured blood...

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Veröffentlicht in:	Neurobiology of aging 2003-03, Vol.24 (2), p.307-313
Hauptverfasser:	Heijer, Tom den, Skoog, Ingmar, Oudkerk, Matthijs, de Leeuw, Frank-Erik, de Groot, Jan Cees, Hofman, Albert, Breteler, Monique M.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Atrophy Biological and medical sciences Blood Pressure Brain Brain - pathology Dementia Dementia - epidemiology Dementia - pathology Development. Senescence. Regeneration. Transplantation Epidemiology Female Fundamental and applied biological sciences. Psychology Humans Hypertension - epidemiology Hypertension - pathology Longitudinal Studies Magnetic Resonance Imaging Male Middle Aged Predictive Value of Tests Risk Factors Vertebrates: nervous system and sense organs
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Zusammenfassung:	The relation between blood pressure level and degree of global brain atrophy is equivocal. We evaluated past and present blood pressure levels and change in blood pressure over 20 years in relation to the degree of cortical atrophy on magnetic resonance imaging (MRI). In 1995–1996, we measured blood pressure and performed MRI in 1077 nondemented elderly (age 60–90 years). For 513 of these, we had information on a blood pressure level 20 years before. The degree of cortical atrophy was semi-quantitatively scored (range 0–15). In late life, a high (≥90 mmHg) and low (
ISSN:	0197-4580 1558-1497
DOI:	10.1016/S0197-4580(02)00088-X