Relation of Birth Weight to Fasting Insulin, Insulin Resistance, and Body Size in Adolescence

Relation of Birth Weight to Fasting Insulin, Insulin Resistance, and Body Size in Adolescence Maureen A. Murtaugh , PHD 1 , David R. Jacobs, Jr. , PHD 1 , Antoinette Moran , MD 2 , Julia Steinberger , MD 2 and Alan R. Sinaiko , MD 2 1 Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 2 Department of Pediatrics, University of Minnesota, Minneapolis, MN Abstract OBJECTIVE —A relationship between birth weight and the insulin resistance syndrome has been reported in adults but has not been defined in adolescents. RESEARCH DESIGN AND METHODS —Data were analyzed in 296 children (132 girls and 164 boys) mean age 15.0 ± 1.2 years who had euglycemic insulin clamp studies (intravenous administration of 1 mU · kg –1 · min –1 of insulin balanced by a variable infusion of 20% glucose to maintain blood glucose at 100 mg/dl). Insulin sensitivity (M LBM ) was determined by glucose uptake per kg lean body mass (LBM), and parents reported birth weight. RESULTS —Birth weight ranged from 1,021 to 4,848 g (mean ± SD 3,433 ± 551), with 4.0%