Lack of midazolam-induced anxiolysis in the plus-maze Trial 2 is dependent on the length of Trial 1

The influence of the first exposure length upon the effect of midazolam (MDZ) administration prior to the second exposure in the elevated plus-maze (EPM) was investigated. Drug-free rats were assigned to freely explore the EPM for 1, 2 or 5 min (Trial 1). Twenty-four hours later, each group was subd...

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Veröffentlicht in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2003, Vol.74 (2), p.395-400
Hauptverfasser: Dal-Cól, M.L.C, Pereira, L.Orlandi, Rosa, V.P, Calixto, A.V, Carobrez, A.P, Faria, M.S
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Sprache:eng
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Zusammenfassung:The influence of the first exposure length upon the effect of midazolam (MDZ) administration prior to the second exposure in the elevated plus-maze (EPM) was investigated. Drug-free rats were assigned to freely explore the EPM for 1, 2 or 5 min (Trial 1). Twenty-four hours later, each group was subdivided in two further groups, which were retested in the EPM for 5 min, 30 min after either saline or MDZ (1.5 mg kg −1) administration (Trial 2). The data showed that during Trial 2, the percentage of entries (%Open arm entries) and time spent in the open arms (%Open arm time) were decreased if rats were pre-exposed to the EPM for 2- or 5-min Trial 1, while the group submitted to 1-min Trial 1 length displayed decreased %Open arm time only. The anxiolytic effect of MDZ prior to Trial 2 was present in the group submitted to 1-min, impaired in the group submitted to 2-min and absent in the group submitted to 5-min Trial 1 length. Data are analyzed taking into account the emotional learning which underlies the exploratory behavior during the EPM Trial 2.
ISSN:0091-3057
1873-5177
DOI:10.1016/S0091-3057(02)01009-2