Bacterial adherence to plain and tobramycin-laden polymethylmethacrylate beads

Antibiotic-impregnated polymethylmethacrylate (PMMA) bead chains are in current clinical use for prophylaxis and management of osteomyelitis. The in vivo interaction between PMMA beads and an experimentally infected wound is examined. Two modes of bacterial adherence to plain PMMA beads are demonstr...

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Veröffentlicht in:	Clinical orthopaedics and related research 1992-05, Vol.278 (278), p.260-264
Hauptverfasser:	Lyons, V O, Henry, S L, Faghiri, M, Seligson, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Adhesion Methylmethacrylates Microscopy, Electron, Scanning Prostheses and Implants Rabbits Staphylococcus aureus - physiology Staphylococcus aureus - ultrastructure Tobramycin - administration & dosage Wound Infection - microbiology
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Beschreibung
Zusammenfassung:	Antibiotic-impregnated polymethylmethacrylate (PMMA) bead chains are in current clinical use for prophylaxis and management of osteomyelitis. The in vivo interaction between PMMA beads and an experimentally infected wound is examined. Two modes of bacterial adherence to plain PMMA beads are demonstrated. In this report, tobramycin-sensitive bacteria did not attach to tobramycin-laden beads. Therefore, implanted PMMA beads should contain an antibiotic to which the infecting bacteria is sensitive.
ISSN:	0009-921X
DOI:	10.1097/00003086-199205000-00039