Effect of genistein, a tyrosine kinase inhibitor, on TAME-esterase induced contractions in rat aorta in vitro
Effect of genistein, a protein tyrosine kinase inhibitor, on TAME-esterase induced contractions were studied on rat aorta strips in vitro. Data showed that TAME-esterase induced contractions were concentration dependent and these contractions were significantly inhibited when rat aorta strips were p...
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| Veröffentlicht in: | Indian journal of experimental biology 2002-10, Vol.40 (10), p.1191-1194 |
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| container_title | Indian journal of experimental biology |
| container_volume | 40 |
| creator | Gurib, F B H Subratty, A H |
| description | Effect of genistein, a protein tyrosine kinase inhibitor, on TAME-esterase induced contractions were studied on rat aorta strips in vitro. Data showed that TAME-esterase induced contractions were concentration dependent and these contractions were significantly inhibited when rat aorta strips were pre-incubated with genistein. The present findings provide evidence for the possible contribution of tyrosine kinases during TAME-esterase induced contractions in aorta. |
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Data showed that TAME-esterase induced contractions were concentration dependent and these contractions were significantly inhibited when rat aorta strips were pre-incubated with genistein. 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Data showed that TAME-esterase induced contractions were concentration dependent and these contractions were significantly inhibited when rat aorta strips were pre-incubated with genistein. 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Data showed that TAME-esterase induced contractions were concentration dependent and these contractions were significantly inhibited when rat aorta strips were pre-incubated with genistein. The present findings provide evidence for the possible contribution of tyrosine kinases during TAME-esterase induced contractions in aorta.</abstract><cop>India</cop><pmid>12693704</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Indian journal of experimental biology, 2002-10, Vol.40 (10), p.1191-1194 |
| issn | 0019-5189 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Aorta - drug effects Aorta - enzymology Aorta - physiology Enzyme Inhibitors - pharmacology Genistein - pharmacology Male Muscle Contraction - drug effects Muscle Contraction - physiology Peptide Hydrolases - physiology Protein-Tyrosine Kinases - antagonists & inhibitors Rats Rats, Sprague-Dawley |
| title | Effect of genistein, a tyrosine kinase inhibitor, on TAME-esterase induced contractions in rat aorta in vitro |
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