Effect of genistein, a tyrosine kinase inhibitor, on TAME-esterase induced contractions in rat aorta in vitro

Effect of genistein, a protein tyrosine kinase inhibitor, on TAME-esterase induced contractions were studied on rat aorta strips in vitro. Data showed that TAME-esterase induced contractions were concentration dependent and these contractions were significantly inhibited when rat aorta strips were p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Indian journal of experimental biology 2002-10, Vol.40 (10), p.1191-1194
Hauptverfasser:	Gurib, F B H, Subratty, A H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Aorta - enzymology Aorta - physiology Enzyme Inhibitors - pharmacology Genistein - pharmacology Male Muscle Contraction - drug effects Muscle Contraction - physiology Peptide Hydrolases - physiology Protein-Tyrosine Kinases - antagonists & inhibitors Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Effect of genistein, a protein tyrosine kinase inhibitor, on TAME-esterase induced contractions were studied on rat aorta strips in vitro. Data showed that TAME-esterase induced contractions were concentration dependent and these contractions were significantly inhibited when rat aorta strips were pre-incubated with genistein. The present findings provide evidence for the possible contribution of tyrosine kinases during TAME-esterase induced contractions in aorta.
ISSN:	0019-5189