The cost-effectiveness of β-radiation therapy for treatment of in-stent restenosis: An analysis at 290-day follow-up
Purpose: We studied the cost-effectiveness of percutaneous coronary intervention (PCI) plus β-radiation (Radiotherapy) vs. PCI alone for treating in-stent restenosis. Methods and materials: We analyzed medical resource data collected at US sites during the Intimal Hyperplasia Inhibition with β In-st...
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| Veröffentlicht in: | Cardiovascular radiation medicine 2002-04, Vol.3 (2), p.107-113 |
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| creator | Beusterien, Kathleen M. Plante, Kathryn M. Waksman, Ron Raizner, Albert E. Annis, Marijke Goss, Thomas F. |
| description | Purpose: We studied the cost-effectiveness of percutaneous coronary intervention (PCI) plus β-radiation (Radiotherapy) vs. PCI alone for treating in-stent restenosis.
Methods and materials: We analyzed medical resource data collected at US sites during the Intimal Hyperplasia Inhibition with β In-stent Trial (INHIBIT) to compare the incremental costs between Radiotherapy and PCI alone for each repeat target lesion revascularization (TLR) avoided. Costs were assigned for cardiac-related medical services using the Medicare payer perspective.
Results: Radiotherapy increased initial inpatient costs by US$3360 (
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| doi_str_mv | 10.1016/S1522-1865(02)00157-9 |
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Methods and materials: We analyzed medical resource data collected at US sites during the Intimal Hyperplasia Inhibition with β In-stent Trial (INHIBIT) to compare the incremental costs between Radiotherapy and PCI alone for each repeat target lesion revascularization (TLR) avoided. Costs were assigned for cardiac-related medical services using the Medicare payer perspective.
Results: Radiotherapy increased initial inpatient costs by US$3360 (
P<.001). In the Radiotherapy and PCI alone groups, the mean per-patient rates for TLR were 0.13 vs. 0.30 (
P=.001), and mean per-patient total costs were US$19,286 vs. US$18,349 (
P<.001), respectively. The incremental cost of Radiotherapy relative to PCI alone was US$5512 per TLR avoided, which compares favorably to the observed mean per-patient cost of treating restenosis (US$16,852).
Conclusions: β-radiation is a cost-effective adjunct to PCI in treating patients with in-stent restenosis.</description><identifier>ISSN: 1522-1865</identifier><identifier>DOI: 10.1016/S1522-1865(02)00157-9</identifier><identifier>PMID: 12699841</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Angioplasty, Balloon, Coronary - economics ; Beta Particles - therapeutic use ; Blood Vessel Prosthesis Implantation - adverse effects ; Blood Vessel Prosthesis Implantation - economics ; Coronary artery disease ; Coronary Artery Disease - economics ; Coronary Artery Disease - surgery ; Coronary restenosis ; Coronary revascularization ; Coronary stent ; Cost-Benefit Analysis ; Cost-effectiveness ; Female ; Graft Occlusion, Vascular - economics ; Graft Occlusion, Vascular - etiology ; Graft Occlusion, Vascular - therapy ; Health Care Costs ; Humans ; INHIBIT trial ; Male ; Middle Aged ; Percutaneous coronary intervention ; Radiotherapy ; Radiotherapy - economics ; Radiotherapy, Adjuvant - economics ; Randomized Controlled Trials as Topic - economics ; Retrospective Studies ; β-radiation</subject><ispartof>Cardiovascular radiation medicine, 2002-04, Vol.3 (2), p.107-113</ispartof><rights>2003 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12699841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beusterien, Kathleen M.</creatorcontrib><creatorcontrib>Plante, Kathryn M.</creatorcontrib><creatorcontrib>Waksman, Ron</creatorcontrib><creatorcontrib>Raizner, Albert E.</creatorcontrib><creatorcontrib>Annis, Marijke</creatorcontrib><creatorcontrib>Goss, Thomas F.</creatorcontrib><title>The cost-effectiveness of β-radiation therapy for treatment of in-stent restenosis: An analysis at 290-day follow-up</title><title>Cardiovascular radiation medicine</title><addtitle>Cardiovasc Radiat Med</addtitle><description>Purpose: We studied the cost-effectiveness of percutaneous coronary intervention (PCI) plus β-radiation (Radiotherapy) vs. PCI alone for treating in-stent restenosis.
Methods and materials: We analyzed medical resource data collected at US sites during the Intimal Hyperplasia Inhibition with β In-stent Trial (INHIBIT) to compare the incremental costs between Radiotherapy and PCI alone for each repeat target lesion revascularization (TLR) avoided. Costs were assigned for cardiac-related medical services using the Medicare payer perspective.
Results: Radiotherapy increased initial inpatient costs by US$3360 (
P<.001). In the Radiotherapy and PCI alone groups, the mean per-patient rates for TLR were 0.13 vs. 0.30 (
P=.001), and mean per-patient total costs were US$19,286 vs. US$18,349 (
P<.001), respectively. The incremental cost of Radiotherapy relative to PCI alone was US$5512 per TLR avoided, which compares favorably to the observed mean per-patient cost of treating restenosis (US$16,852).
Conclusions: β-radiation is a cost-effective adjunct to PCI in treating patients with in-stent restenosis.</description><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary - economics</subject><subject>Beta Particles - therapeutic use</subject><subject>Blood Vessel Prosthesis Implantation - adverse effects</subject><subject>Blood Vessel Prosthesis Implantation - economics</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - economics</subject><subject>Coronary Artery Disease - surgery</subject><subject>Coronary restenosis</subject><subject>Coronary revascularization</subject><subject>Coronary stent</subject><subject>Cost-Benefit Analysis</subject><subject>Cost-effectiveness</subject><subject>Female</subject><subject>Graft Occlusion, Vascular - economics</subject><subject>Graft Occlusion, Vascular - etiology</subject><subject>Graft Occlusion, Vascular - therapy</subject><subject>Health Care Costs</subject><subject>Humans</subject><subject>INHIBIT trial</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Percutaneous coronary intervention</subject><subject>Radiotherapy</subject><subject>Radiotherapy - economics</subject><subject>Radiotherapy, Adjuvant - economics</subject><subject>Randomized Controlled Trials as Topic - economics</subject><subject>Retrospective Studies</subject><subject>β-radiation</subject><issn>1522-1865</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1OAyEUhVlotP48goaV0QUKTIcZ3Bhj_EuauLCuCYVLipkOFZiavpYP4jM5U6ure-F-3BzOQeiE0UtGmbh6ZSXnhNWiPKf8glJWVkTuoNH_9T46SOm9HwhZVHton3EhZT1mI9RN54BNSJmAc2CyX0ELKeHg8PcXidp6nX1ocZ5D1Ms1diHiHEHnBbR5oHxLUh76CEMNyadrfNti3epm3R-wzphLSqweHjdN-CTd8gjtOt0kON7WQ_T2cD-9eyKTl8fnu9sJAVbVmdhxUVADnHIjKsGFM9bUpXaaWcEZSDv8h5aOzoQbSyGqEsrSzuqZ5oY7CsUhOvvdu4zho-sFqoVPBppGtxC6pCpeV1Uxlj14ugW72QKsWka_0HGt_ozqgZtfAHq5Kw9RJeOhNWB97G1TNnjFqBriUJs41OC7olxt4lCy-AGe-X-B</recordid><startdate>200204</startdate><enddate>200204</enddate><creator>Beusterien, Kathleen M.</creator><creator>Plante, Kathryn M.</creator><creator>Waksman, Ron</creator><creator>Raizner, Albert E.</creator><creator>Annis, Marijke</creator><creator>Goss, Thomas F.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200204</creationdate><title>The cost-effectiveness of β-radiation therapy for treatment of in-stent restenosis: An analysis at 290-day follow-up</title><author>Beusterien, Kathleen M. ; Plante, Kathryn M. ; Waksman, Ron ; Raizner, Albert E. ; Annis, Marijke ; Goss, Thomas F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e178t-d4330ce202c67626fcdc85afa1d621e9d169305f0b6f496675e55db8ba2c2f0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Angioplasty, Balloon, Coronary - economics</topic><topic>Beta Particles - therapeutic use</topic><topic>Blood Vessel Prosthesis Implantation - adverse effects</topic><topic>Blood Vessel Prosthesis Implantation - economics</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - economics</topic><topic>Coronary Artery Disease - surgery</topic><topic>Coronary restenosis</topic><topic>Coronary revascularization</topic><topic>Coronary stent</topic><topic>Cost-Benefit Analysis</topic><topic>Cost-effectiveness</topic><topic>Female</topic><topic>Graft Occlusion, Vascular - economics</topic><topic>Graft Occlusion, Vascular - etiology</topic><topic>Graft Occlusion, Vascular - therapy</topic><topic>Health Care Costs</topic><topic>Humans</topic><topic>INHIBIT trial</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Percutaneous coronary intervention</topic><topic>Radiotherapy</topic><topic>Radiotherapy - economics</topic><topic>Radiotherapy, Adjuvant - economics</topic><topic>Randomized Controlled Trials as Topic - economics</topic><topic>Retrospective Studies</topic><topic>β-radiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beusterien, Kathleen M.</creatorcontrib><creatorcontrib>Plante, Kathryn M.</creatorcontrib><creatorcontrib>Waksman, Ron</creatorcontrib><creatorcontrib>Raizner, Albert E.</creatorcontrib><creatorcontrib>Annis, Marijke</creatorcontrib><creatorcontrib>Goss, Thomas F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular radiation medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beusterien, Kathleen M.</au><au>Plante, Kathryn M.</au><au>Waksman, Ron</au><au>Raizner, Albert E.</au><au>Annis, Marijke</au><au>Goss, Thomas F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The cost-effectiveness of β-radiation therapy for treatment of in-stent restenosis: An analysis at 290-day follow-up</atitle><jtitle>Cardiovascular radiation medicine</jtitle><addtitle>Cardiovasc Radiat Med</addtitle><date>2002-04</date><risdate>2002</risdate><volume>3</volume><issue>2</issue><spage>107</spage><epage>113</epage><pages>107-113</pages><issn>1522-1865</issn><abstract>Purpose: We studied the cost-effectiveness of percutaneous coronary intervention (PCI) plus β-radiation (Radiotherapy) vs. PCI alone for treating in-stent restenosis.
Methods and materials: We analyzed medical resource data collected at US sites during the Intimal Hyperplasia Inhibition with β In-stent Trial (INHIBIT) to compare the incremental costs between Radiotherapy and PCI alone for each repeat target lesion revascularization (TLR) avoided. Costs were assigned for cardiac-related medical services using the Medicare payer perspective.
Results: Radiotherapy increased initial inpatient costs by US$3360 (
P<.001). In the Radiotherapy and PCI alone groups, the mean per-patient rates for TLR were 0.13 vs. 0.30 (
P=.001), and mean per-patient total costs were US$19,286 vs. US$18,349 (
P<.001), respectively. The incremental cost of Radiotherapy relative to PCI alone was US$5512 per TLR avoided, which compares favorably to the observed mean per-patient cost of treating restenosis (US$16,852).
Conclusions: β-radiation is a cost-effective adjunct to PCI in treating patients with in-stent restenosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12699841</pmid><doi>10.1016/S1522-1865(02)00157-9</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Angioplasty, Balloon, Coronary - economics Beta Particles - therapeutic use Blood Vessel Prosthesis Implantation - adverse effects Blood Vessel Prosthesis Implantation - economics Coronary artery disease Coronary Artery Disease - economics Coronary Artery Disease - surgery Coronary restenosis Coronary revascularization Coronary stent Cost-Benefit Analysis Cost-effectiveness Female Graft Occlusion, Vascular - economics Graft Occlusion, Vascular - etiology Graft Occlusion, Vascular - therapy Health Care Costs Humans INHIBIT trial Male Middle Aged Percutaneous coronary intervention Radiotherapy Radiotherapy - economics Radiotherapy, Adjuvant - economics Randomized Controlled Trials as Topic - economics Retrospective Studies β-radiation |
| title | The cost-effectiveness of β-radiation therapy for treatment of in-stent restenosis: An analysis at 290-day follow-up |
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