Segregation of the growth slowing effects of valproic acid from phenytoin and carbamazepine on lymphoid tumor cells
One human and six murine tumor cell lines of lymphoid origin were assessed for growth in the presence of three commonly used antiepileptic drugs (AEDs). All seven lines were sensitive to the growth slowing effects of phenytoin (PHT) and carbamazepine (CBZ). Six lines showed a similar effect when exp...
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| Veröffentlicht in: | Life sciences (1973) 1992, Vol.50 (14), p.PL79-PL83 |
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| container_end_page | PL83 |
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| container_issue | 14 |
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| container_title | Life sciences (1973) |
| container_volume | 50 |
| creator | Tittle, Thomas V. Schaumann, Blanka A. Rainey, Joan E. Taylor, Kalama |
| description | One human and six murine tumor cell lines of lymphoid origin were assessed for growth in the presence of three commonly used antiepileptic drugs (AEDs). All seven lines were sensitive to the growth slowing effects of phenytoin (PHT) and carbamazepine (CBZ). Six lines showed a similar effect when exposed to valproic acid (VPA), while one murine B cell line was resistant to inhibition of growth by VPA. |
| doi_str_mv | 10.1016/0024-3205(92)90104-W |
| format | Article |
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All seven lines were sensitive to the growth slowing effects of phenytoin (PHT) and carbamazepine (CBZ). 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| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1992, Vol.50 (14), p.PL79-PL83 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72874144 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Carbamazepine - metabolism Carbamazepine - pharmacology Cell Division - drug effects Culture Techniques - methods Humans Kinetics Leukemia Lymphoma Phenytoin - metabolism Phenytoin - pharmacology Regression Analysis Valproic Acid - metabolism Valproic Acid - pharmacology |
| title | Segregation of the growth slowing effects of valproic acid from phenytoin and carbamazepine on lymphoid tumor cells |
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