Segregation of the growth slowing effects of valproic acid from phenytoin and carbamazepine on lymphoid tumor cells

Segregation of the growth slowing effects of valproic acid from phenytoin and carbamazepine on lymphoid tumor cells

One human and six murine tumor cell lines of lymphoid origin were assessed for growth in the presence of three commonly used antiepileptic drugs (AEDs). All seven lines were sensitive to the growth slowing effects of phenytoin (PHT) and carbamazepine (CBZ). Six lines showed a similar effect when exp...

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Veröffentlicht in:Life sciences (1973) 1992, Vol.50 (14), p.PL79-PL83
Hauptverfasser: Tittle, Thomas V., Schaumann, Blanka A., Rainey, Joan E., Taylor, Kalama
Format: Artikel
Sprache:eng
Schlagworte:
Carbamazepine - metabolism
Carbamazepine - pharmacology
Cell Division - drug effects
Culture Techniques - methods
Humans
Kinetics
Leukemia
Lymphoma
Phenytoin - metabolism
Phenytoin - pharmacology
Regression Analysis
Valproic Acid - metabolism
Valproic Acid - pharmacology
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Zusammenfassung:One human and six murine tumor cell lines of lymphoid origin were assessed for growth in the presence of three commonly used antiepileptic drugs (AEDs). All seven lines were sensitive to the growth slowing effects of phenytoin (PHT) and carbamazepine (CBZ). Six lines showed a similar effect when exposed to valproic acid (VPA), while one murine B cell line was resistant to inhibition of growth by VPA.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(92)90104-W