A case of skin hyperpigmentation due to α‐MSH hypersecretion

Summary A case is presented of generalized skin hyperpigmentation due to α‐MSH hypersecretion from the pituitary that was most marked in the light‐exposed areas. The patient also had secondary adrenal dysfunction, peripheral lymphadenopathy, streptococcal glomerulonephritis and malabsorption. Analysis of this patient's α‐MSH using high‐pressure liquid chromatography (HPLC) showed a novel acetylation profile compared to normal individuals and to patients with Cushing's disease and Nelson's syndrome. Glucocorticoid replacement therapy resulted in suppression of α‐MSH hypersecretion and complete resolution of the illness.