QUARTROMICIN, A COMPLEX OF NOVEL ANTIVIRAL ANTIBIOTICS: I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND ANTIVIRAL ACTIVITY
A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known ant...
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| Veröffentlicht in: | Journal of antibiotics 1992/02/25, Vol.45(2), pp.180-188 |
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| container_title | Journal of antibiotics |
| container_volume | 45 |
| creator | TSUNAKAWA, MITSUAKI TENMYO, OSAMU TOMITA, KOJI NARUSE, NOBUAKI KOTAKE, CHIKAKO MIYAKI, TAKEO KONISHI, MASATAKA OKI, TOSHIKAZU |
| description | A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex virus type 1, influenza virus type A and human immunodeficiency virus. |
| doi_str_mv | 10.7164/antibiotics.45.180 |
| format | Article |
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PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND ANTIVIRAL ACTIVITY</title><source>J-STAGE Free</source><source>MEDLINE</source><creator>TSUNAKAWA, MITSUAKI ; TENMYO, OSAMU ; TOMITA, KOJI ; NARUSE, NOBUAKI ; KOTAKE, CHIKAKO ; MIYAKI, TAKEO ; KONISHI, MASATAKA ; OKI, TOSHIKAZU</creator><creatorcontrib>TSUNAKAWA, MITSUAKI ; TENMYO, OSAMU ; TOMITA, KOJI ; NARUSE, NOBUAKI ; KOTAKE, CHIKAKO ; MIYAKI, TAKEO ; KONISHI, MASATAKA ; OKI, TOSHIKAZU</creatorcontrib><description>A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex virus type 1, influenza virus type A and human immunodeficiency virus.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.45.180</identifier><identifier>PMID: 1313409</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Actinomycetales - classification ; Actinomycetales - metabolism ; AIDS/HIV ; Amycolatopsis orientalis ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Antiviral Agents - chemistry ; Antiviral Agents - isolation & purification ; Antiviral Agents - metabolism ; Antiviral Agents - pharmacology ; Biological and medical sciences ; Chemical Phenomena ; Chemistry, Physical ; Fermentation ; herpes simplex virus 1 ; human immunodeficiency virus ; influenza A virus ; Lactones - chemistry ; Lactones - isolation & purification ; Lactones - metabolism ; Lactones - pharmacology ; Magnetic Resonance Spectroscopy ; Medical sciences ; Orthomyxoviridae - drug effects ; Pharmacology. Drug treatments ; Simplexvirus - drug effects ; Spiro Compounds - chemistry ; Spiro Compounds - isolation & purification ; Spiro Compounds - metabolism ; Spiro Compounds - pharmacology ; Vero Cells</subject><ispartof>The Journal of Antibiotics, 1992/02/25, Vol.45(2), pp.180-188</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3830-9ddbc6af3c5db748efbdcad1ac2205a076d947d93e9478430666d060db7ae0f63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5319331$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1313409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TSUNAKAWA, MITSUAKI</creatorcontrib><creatorcontrib>TENMYO, OSAMU</creatorcontrib><creatorcontrib>TOMITA, KOJI</creatorcontrib><creatorcontrib>NARUSE, NOBUAKI</creatorcontrib><creatorcontrib>KOTAKE, CHIKAKO</creatorcontrib><creatorcontrib>MIYAKI, TAKEO</creatorcontrib><creatorcontrib>KONISHI, MASATAKA</creatorcontrib><creatorcontrib>OKI, TOSHIKAZU</creatorcontrib><title>QUARTROMICIN, A COMPLEX OF NOVEL ANTIVIRAL ANTIBIOTICS: I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND ANTIVIRAL ACTIVITY</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex virus type 1, influenza virus type A and human immunodeficiency virus.</description><subject>Actinomycetales - classification</subject><subject>Actinomycetales - metabolism</subject><subject>AIDS/HIV</subject><subject>Amycolatopsis orientalis</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - isolation & purification</subject><subject>Antiviral Agents - metabolism</subject><subject>Antiviral Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Fermentation</subject><subject>herpes simplex virus 1</subject><subject>human immunodeficiency virus</subject><subject>influenza A virus</subject><subject>Lactones - chemistry</subject><subject>Lactones - isolation & purification</subject><subject>Lactones - metabolism</subject><subject>Lactones - pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Orthomyxoviridae - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Simplexvirus - drug effects</subject><subject>Spiro Compounds - chemistry</subject><subject>Spiro Compounds - isolation & purification</subject><subject>Spiro Compounds - metabolism</subject><subject>Spiro Compounds - pharmacology</subject><subject>Vero Cells</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1OwzAQhC0EglJ4ASSkHBAnUtaxYzvHEBWIKA2UgrhZju1AUPpD3B54e4xSFW5cdleab3dWg9AJhgHHjF6q-aou68Wq1m5A4wEWsIN6WAgcYsqSXdQDiHAoRAQH6NC5DwDCCRf7aB8TTCgkPcQen9PJdFLc51k-vgjSICvuH0bD16C4DsbFy3AUpONp_pJP0m66yotpnj0dob1KNc4eb3ofPV8Pp9ltOCpu8iwdhZoIAmFiTKmZqoiOTcmpsFVptDJY6SiCWAFnJqHcJMT6JigBxpgBBh5WFipG-ui8u7tsF59r61ZyVjttm0bN7WLtJI8EY8DFvyBmRGBOYw9GHajbhXOtreSyrWeq_ZIY5E-q8k-qksbSp-qXTjfX1-XMmt-VLkavn2105bRqqlbNde22WExwQjzaR3cd9uFW6s1uddV6s8b-dcYJEz_uUVf8E1tKv6tW2jn5BmLXmEs</recordid><startdate>19920101</startdate><enddate>19920101</enddate><creator>TSUNAKAWA, MITSUAKI</creator><creator>TENMYO, OSAMU</creator><creator>TOMITA, KOJI</creator><creator>NARUSE, NOBUAKI</creator><creator>KOTAKE, CHIKAKO</creator><creator>MIYAKI, TAKEO</creator><creator>KONISHI, MASATAKA</creator><creator>OKI, TOSHIKAZU</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19920101</creationdate><title>QUARTROMICIN, A COMPLEX OF NOVEL ANTIVIRAL ANTIBIOTICS</title><author>TSUNAKAWA, MITSUAKI ; TENMYO, OSAMU ; TOMITA, KOJI ; NARUSE, NOBUAKI ; KOTAKE, CHIKAKO ; MIYAKI, TAKEO ; KONISHI, MASATAKA ; OKI, TOSHIKAZU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3830-9ddbc6af3c5db748efbdcad1ac2205a076d947d93e9478430666d060db7ae0f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Actinomycetales - classification</topic><topic>Actinomycetales - metabolism</topic><topic>AIDS/HIV</topic><topic>Amycolatopsis orientalis</topic><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - chemistry</topic><topic>Antiviral Agents - isolation & purification</topic><topic>Antiviral Agents - metabolism</topic><topic>Antiviral Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Fermentation</topic><topic>herpes simplex virus 1</topic><topic>human immunodeficiency virus</topic><topic>influenza A virus</topic><topic>Lactones - chemistry</topic><topic>Lactones - isolation & purification</topic><topic>Lactones - metabolism</topic><topic>Lactones - pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Orthomyxoviridae - drug effects</topic><topic>Pharmacology. 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PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND ANTIVIRAL ACTIVITY</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1992-01-01</date><risdate>1992</risdate><volume>45</volume><issue>2</issue><spage>180</spage><epage>188</epage><pages>180-188</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. 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| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1992/02/25, Vol.45(2), pp.180-188 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | J-STAGE Free; MEDLINE |
| subjects | Actinomycetales - classification Actinomycetales - metabolism AIDS/HIV Amycolatopsis orientalis Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - metabolism Antiviral Agents - pharmacology Biological and medical sciences Chemical Phenomena Chemistry, Physical Fermentation herpes simplex virus 1 human immunodeficiency virus influenza A virus Lactones - chemistry Lactones - isolation & purification Lactones - metabolism Lactones - pharmacology Magnetic Resonance Spectroscopy Medical sciences Orthomyxoviridae - drug effects Pharmacology. Drug treatments Simplexvirus - drug effects Spiro Compounds - chemistry Spiro Compounds - isolation & purification Spiro Compounds - metabolism Spiro Compounds - pharmacology Vero Cells |
| title | QUARTROMICIN, A COMPLEX OF NOVEL ANTIVIRAL ANTIBIOTICS: I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND ANTIVIRAL ACTIVITY |
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