QUARTROMICIN, A COMPLEX OF NOVEL ANTIVIRAL ANTIBIOTICS: I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND ANTIVIRAL ACTIVITY

A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known ant...

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Veröffentlicht in:Journal of antibiotics 1992/02/25, Vol.45(2), pp.180-188
Hauptverfasser: TSUNAKAWA, MITSUAKI, TENMYO, OSAMU, TOMITA, KOJI, NARUSE, NOBUAKI, KOTAKE, CHIKAKO, MIYAKI, TAKEO, KONISHI, MASATAKA, OKI, TOSHIKAZU
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Sprache:eng
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Zusammenfassung:A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex virus type 1, influenza virus type A and human immunodeficiency virus.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.180