QUARTROMICIN, A COMPLEX OF NOVEL ANTIVIRAL ANTIBIOTICS: I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND ANTIVIRAL ACTIVITY
A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known ant...
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Veröffentlicht in: | Journal of antibiotics 1992/02/25, Vol.45(2), pp.180-188 |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex virus type 1, influenza virus type A and human immunodeficiency virus. |
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ISSN: | 0021-8820 1881-1469 |
DOI: | 10.7164/antibiotics.45.180 |