Superiority of L-propionylcarnitine vs L-carnitine in improving walking capacity in patients with peripheral vascular disease: an acute, intravenous, double-blind, cross-over study

The effects of L-propionylcarnitine on walking capacity were assessed in a group of patients with peripheral vascular disease. in 12 patients. 300mg of L-propnionylcarnitine, given intravenously as a single bolus did not affect walking capacity, while 600mg increased both initial claudication distan...

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Veröffentlicht in:	European heart journal 1992-02, Vol.13 (2), p.251-255
Hauptverfasser:	BREVETTI, G., PERNA, S., SABBÀ, C., ROSSINI, A., SCOTTO DI UCCIO, V., BERARDI, E., GODI, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arterial Occlusive Diseases - drug therapy Biological and medical sciences Cardiovascular system Carnitine - administration & dosage Carnitine - analogs & derivatives Dose-Response Relationship, Drug Double-Blind Method Exercise Test - drug effects Hemodynamics - drug effects Humans Infusions, Intravenous Intermittent Claudication - drug therapy Ischemia - drug therapy L-carnitine L-propionylcarnitine Leg - blood supply Male Medical sciences Middle Aged peripheral vascular disease Pharmacology. Drug treatments Vasodilator agents. Cerebral vasodilators walking capacity
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Zusammenfassung:	The effects of L-propionylcarnitine on walking capacity were assessed in a group of patients with peripheral vascular disease. in 12 patients. 300mg of L-propnionylcarnitine, given intravenously as a single bolus did not affect walking capacity, while 600mg increased both initial claudication distance from the placebo value of 179±114 to 245 ± 129 m (P
ISSN:	0195-668X 1522-9645
DOI:	10.1093/oxfordjournals.eurheartj.a060155