Dose-dependent down-regulation of β-adrenoceptors by isoproterenol in rat C6 glioma cells
Nano- and micromolar isoproterenol concentrations were compared by studying cyclic AMP, beta-adrenoceptor density and beta 1-adrenoceptor mRNA in rat C6 glioma cells. 1 microM isoproterenol significantly changed all parameters at 15-30 min. The beta 1-antagonist metoprolol attenuated the response. N...
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Veröffentlicht in: | European journal of pharmacology 1992-02, Vol.225 (2), p.171-174 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Nano- and micromolar isoproterenol concentrations were compared by studying cyclic AMP, beta-adrenoceptor density and beta 1-adrenoceptor mRNA in rat C6 glioma cells. 1 microM isoproterenol significantly changed all parameters at 15-30 min. The beta 1-antagonist metoprolol attenuated the response. No effects of nanomolar isoproterenol on these early changes were observed, although the density of beta-adrenoceptors was significantly reduced beginning at 12 h. The results indicate a different process for beta-adrenoceptor desensitization in C6 cells following physiologically low agonist concentrations. |
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ISSN: | 0922-4106 0014-2999 |
DOI: | 10.1016/0922-4106(92)90098-G |